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Periostin Mediates Oestrogen-Induced Osteogenic Differentiation of Bone Marrow Stromal Cells in Ovariectomised Rats
Joint Authors
Liu, Jia
Jin, Zuolin
Li, Chunrong
Li, Xin
Wang, Xian
Miao, Pei
Li, Cuixia
Li, Doudou
Zhou, Weiwei
Cao, Meng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Osteoporosis is a metabolic disease that results in the progressive loss of bone mass, which, in postmenopausal women, is related to oestrogen deficiency.
Periostin (POSTN) plays a key role in the early stages of bone formation.
However, whether POSTN participates in oestradiol regulation of osteogenic differentiation of bone marrow stromal cells (BMSCs) from ovariectomised (OVX) rats remains unclear.
In vivo, using microcomputed tomography (micro-CT), immunohistochemistry, and dynamic analysis of femurs, we found that 17β-E2 promotes bone formation and POSTN expression at the endosteal surface.
In vitro, 17β-E2 upregulated POSTN expression in OVX-BMSCs.
POSTN overexpression activated the Wnt/β-catenin signalling pathway and enhanced osteogenic differentiation of OVX-BMSCs.
Furthermore, knockdown of Postn blocks the involvement of 17β-E2 in the osteogenic differentiation of OVX-BMSCs.
Collectively, our study indicated the role of POSTN in the osteogenesis and stemness of OVX-BMSCs and proves that 17β-E2 reduces osteoporosis and promotes osteogenesis through the POSTN-Wnt/β-catenin pathway.
POSTN could, therefore, be a novel target gene for anti-osteoporosis therapies.
American Psychological Association (APA)
Li, Chunrong& Li, Xin& Wang, Xian& Miao, Pei& Liu, Jia& Li, Cuixia…[et al.]. 2020. Periostin Mediates Oestrogen-Induced Osteogenic Differentiation of Bone Marrow Stromal Cells in Ovariectomised Rats. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138108
Modern Language Association (MLA)
Li, Chunrong…[et al.]. Periostin Mediates Oestrogen-Induced Osteogenic Differentiation of Bone Marrow Stromal Cells in Ovariectomised Rats. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1138108
American Medical Association (AMA)
Li, Chunrong& Li, Xin& Wang, Xian& Miao, Pei& Liu, Jia& Li, Cuixia…[et al.]. Periostin Mediates Oestrogen-Induced Osteogenic Differentiation of Bone Marrow Stromal Cells in Ovariectomised Rats. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138108
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138108