Expression Profiling of Cellular MicroRNA in Asymptomatic HBsAg Carriers and Chronic Hepatitis B Patients
Joint Authors
Hou, Xianliang
Liang, Yan
Chen, Jianing
Wei, Yingfeng
Zeng, Ping
Wang, Lin
Lu, Chong
Diao, Hongyan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-23
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Background.
MicroRNAs (miRNAs) may serve as potential molecular markers to predict liver injury resulting from chronic hepatitis B (CHB).
In the present study, we want to study the expression profile and clinical significance of miRNAs at different stages of CHB virus infection.
Methods.
Using miRNA microarray, we investigated the global expression profiles of cellular miRNA in asymptomatic hepatitis B antigen carriers (ASCs) and CHB patients, compared with healthy controls (HCs).
Results.
We identified 79 and 203 differentially expressed miRNAs in the peripheral blood mononuclear cells of ASCs and CHB patients compared to HCs, respectively.
Some of these miRNAs were common to ASCs and CHB patients, but another set of miRNAs that showed differential expression between ASCs and CHB patients was also identified.
Gene ontology and pathway enrichment analysis showed that the target genes of the identified miRNAs played a role in important biological functions, such as learning or memory, cell-cell adherens junction, ion channel inhibitor activity, TGF-beta signaling pathway, and p53 signaling pathway.
Conclusion.
We identified some significant differentially expressed miRNA in different phases of HBV infection, which might serve as biomarkers or therapeutic targets in the future.
American Psychological Association (APA)
Hou, Xianliang& Liang, Yan& Chen, Jianing& Wei, Yingfeng& Zeng, Ping& Wang, Lin…[et al.]. 2017. Expression Profiling of Cellular MicroRNA in Asymptomatic HBsAg Carriers and Chronic Hepatitis B Patients. BioMed Research International،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1138112
Modern Language Association (MLA)
Hou, Xianliang…[et al.]. Expression Profiling of Cellular MicroRNA in Asymptomatic HBsAg Carriers and Chronic Hepatitis B Patients. BioMed Research International No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1138112
American Medical Association (AMA)
Hou, Xianliang& Liang, Yan& Chen, Jianing& Wei, Yingfeng& Zeng, Ping& Wang, Lin…[et al.]. Expression Profiling of Cellular MicroRNA in Asymptomatic HBsAg Carriers and Chronic Hepatitis B Patients. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1138112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138112