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MicroRNA-Related Polymorphisms in PI3KAktmTOR Pathway Genes Are Predictive of Limited-Disease Small Cell Lung Cancer Treatment Outcomes
Joint Authors
Jiang, Wei
Zhang, Wenjue
Wu, Lihong
Liu, Lipin
Men, Yu
Wang, Jingbo
Liang, Jun
Hui, Zhouguang
Zhou, Zongmei
Bi, Nan
Wang, Luhua
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The phosphoinositide-3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway plays an important role in cancer progression and treatment, including that of small cell lung cancer (SCLC), a disease with traditionally poor prognosis.
Given the regulatory role of microRNA (miRNA) in gene expression, we examined the association of single nucleotide polymorphisms (SNPs) at miRNA-binding sites of genes in the mTOR pathway with the prognosis of patients with limited-disease SCLC.
A retrospective study was conducted of 146 patients with limited-disease SCLC treated with chemoradiotherapy.
Nine SNPs of six mTOR pathway genes were genotyped using blood samples.
Cox proportional hazard regression modeling and recursive partitioning analysis were performed to identify SNPs significantly associated with overall survival.
Three SNPs, MTOR: rs2536 (T>C), PIK3R1: rs3756668 (A>G), and PIK3R1: rs12755 (A>C), were associated with longer overall survival.
Recursive partitioning analysis based on unfavorable genotype combinations of the rs2536 and rs3756668 SNPs classified patients into three risk subgroups and was internally validated with 1000 bootstrap samples.
These findings suggest that miRNA-related polymorphisms in the PI3K/Akt/mTOR pathway may be valuable biomarkers to complement clinicopathological variables in predicting prognosis of limited-disease SCLC and to facilitate selection of patients likely to benefit from chemoradiotherapy.
American Psychological Association (APA)
Jiang, Wei& Zhang, Wenjue& Wu, Lihong& Liu, Lipin& Men, Yu& Wang, Jingbo…[et al.]. 2017. MicroRNA-Related Polymorphisms in PI3KAktmTOR Pathway Genes Are Predictive of Limited-Disease Small Cell Lung Cancer Treatment Outcomes. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138123
Modern Language Association (MLA)
Jiang, Wei…[et al.]. MicroRNA-Related Polymorphisms in PI3KAktmTOR Pathway Genes Are Predictive of Limited-Disease Small Cell Lung Cancer Treatment Outcomes. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1138123
American Medical Association (AMA)
Jiang, Wei& Zhang, Wenjue& Wu, Lihong& Liu, Lipin& Men, Yu& Wang, Jingbo…[et al.]. MicroRNA-Related Polymorphisms in PI3KAktmTOR Pathway Genes Are Predictive of Limited-Disease Small Cell Lung Cancer Treatment Outcomes. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138123