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Myocardial Perfusion in Rheumatoid Arthritis Patients: Associations with Traditional Risk Factors and Novel Biomarkers
Joint Authors
Bernardes, Miguel
Pereira, Jorge
Martins, Maria João
Costa, Lúcia
Vieira, Tiago S.
Lucas, Raquel
Ventura, Francisco
Martins, Elisabete
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
Cardiovascular (CV) diseases are a major cause of death in rheumatoid arthritis (RA) patients.
Novel biomarkers [B-type natriuretic peptide (BNP); osteoprotegerin (OPG)/receptor activator of nuclear factor-kappa B ligand (RANKL) ratio; and dickkopf-1 (DKK-1)] have been used in CV risk assessment.
We analysed, in established RA patients, the presence of silent myocardial ischemia and its association with clinical variables, BNP, and bone and atheroma biomarkers.
Methods.
From a single-center tertiary referral hospital, RA patients asymptomatic for CV disease were submitted to myocardial perfusion scintigraphy (MPS) under adenosine stress and biomarkers measurements.
Logistic regression was used to estimate crude odds ratios (OR) and 95% confidence intervals (CI).
Results.
In 189 patients, perfusion defects were frequent (25%) and associated with BNP ≥ 100 pg/mL (OR = 5.68; 95% CI: 2.038–15.830), fourth log OPG/RANKL ratio quartile (OR = 2.88; 95% CI: 1.091–7.622), and DKK-1 ≥ 133 pmol/L (OR = 2.69; 95% CI: 1.058–6.840).
Similar associations were confirmed in those with C-reactive protein > or ≤ 3 mg/L.
No relationship was found with the majority of traditional CV factors nor with disease variables.
Conclusions.
Our results corroborated the hypothesis that MPS could reveal subclinical CV dysfunction, supported the utility of BNP measurements as a screening tool, and put in perspective the potential usefulness of complementary approaches in CV risk assessment in RA patients.
American Psychological Association (APA)
Bernardes, Miguel& Vieira, Tiago S.& Martins, Maria João& Lucas, Raquel& Costa, Lúcia& Pereira, Jorge…[et al.]. 2017. Myocardial Perfusion in Rheumatoid Arthritis Patients: Associations with Traditional Risk Factors and Novel Biomarkers. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138127
Modern Language Association (MLA)
Bernardes, Miguel…[et al.]. Myocardial Perfusion in Rheumatoid Arthritis Patients: Associations with Traditional Risk Factors and Novel Biomarkers. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1138127
American Medical Association (AMA)
Bernardes, Miguel& Vieira, Tiago S.& Martins, Maria João& Lucas, Raquel& Costa, Lúcia& Pereira, Jorge…[et al.]. Myocardial Perfusion in Rheumatoid Arthritis Patients: Associations with Traditional Risk Factors and Novel Biomarkers. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138127