Ginsenoside Rg1 Ameliorates Cigarette Smoke-Induced Airway Fibrosis by Suppressing the TGF-β1Smad Pathway In Vivo and In Vitro
Joint Authors
Xu, Wei
Han, Fengfeng
Zhang, Yue
Guo, Xue-Jun
Guan, Si-bin
Gu, Wen
Liu, Qian
Song, Lin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Small airway fibrosis is a key pathological process accompanying chronic obstructive pulmonary disease (COPD) and includes fibroblast/myofibroblast transdifferentiation and excessive extracellular matrix deposition.
Ginsenoside Rg1, one of the main active ingredients of Panax ginseng, has been shown to exert an antifibrotic effect in many tissues.
However, little is known about the underlying mechanism and whether ginsenoside Rg1 can exert an effect on small airway fibrosis.
We investigated the anti-small airway fibrosis effects of ginsenoside Rg1 in human embryonic lung fibroblasts and in COPD rats.
We found that ginsenoside Rg1 effectively reduced the degree of pulmonary fibrosis, decreased the expression of α-smooth muscle actin, collagen I, and matrix metalloproteinase 9, and maintained the ratio of matrix metalloproteinase 9 to tissue inhibitor of metalloproteinase 1.
Importantly, ginsenoside Rg1 significantly attenuated cigarette smoke extract-induced upregulation of transforming growth factor β1, TGF-β receptor I, phospho-Smad2, and phospho-Smad3.
In addition, ginsenoside Rg1 mimicked the effect of SB525334, a TGF-β receptor I-Smad2/3 inhibitor.
Collectively, these results suggest that ginsenoside Rg1 may suppress cigarette smoke-induced airway fibrosis in pulmonary fibroblasts and COPD rats by inhibiting the TGF-β1/Smad signaling pathway.
American Psychological Association (APA)
Guan, Si-bin& Liu, Qian& Han, Fengfeng& Gu, Wen& Song, Lin& Zhang, Yue…[et al.]. 2017. Ginsenoside Rg1 Ameliorates Cigarette Smoke-Induced Airway Fibrosis by Suppressing the TGF-β1Smad Pathway In Vivo and In Vitro. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138129
Modern Language Association (MLA)
Guan, Si-bin…[et al.]. Ginsenoside Rg1 Ameliorates Cigarette Smoke-Induced Airway Fibrosis by Suppressing the TGF-β1Smad Pathway In Vivo and In Vitro. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1138129
American Medical Association (AMA)
Guan, Si-bin& Liu, Qian& Han, Fengfeng& Gu, Wen& Song, Lin& Zhang, Yue…[et al.]. Ginsenoside Rg1 Ameliorates Cigarette Smoke-Induced Airway Fibrosis by Suppressing the TGF-β1Smad Pathway In Vivo and In Vitro. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138129