Antioxidant Function and Metabolomics Study in Mice after Dietary Supplementation with Methionine
Joint Authors
Yu, Manrong
Chen, Hui
Liu, Pan
Yang, Mei
Zou, Leqin
Xiao, Dingfu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The antioxidant function and metabolic profiles in mice after dietary supplementation with methionine were investigated.
The results showed that methionine supplementation enhanced liver GSH-Px activity and upregulated Gpx1 expression in the liver and SOD1 and Gpx4 expressions in the jejunum.
Nrf2/Keap1 is involved in oxidative stress, and the western blotting data exhibited that dietary methionine markedly increased Keap1 abundance, while failed to influence the Nrf2 signal.
Metabolomics investigation showed that methionine administration increased 2-hydroxypyridine, salicin, and asparagine and reduced D-Talose, maltose, aminoisobutyric acid, and inosine 5’-monophosphate in the liver, which are widely reported to involve in oxidative stress, lipid metabolism, and nucleotides generation.
In conclusion, our study provides insights into antioxidant function and liver metabolic profiles in response to dietary supplementation with methionine.
American Psychological Association (APA)
Yu, Manrong& Chen, Hui& Liu, Pan& Yang, Mei& Zou, Leqin& Xiao, Dingfu. 2020. Antioxidant Function and Metabolomics Study in Mice after Dietary Supplementation with Methionine. BioMed Research International،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1138133
Modern Language Association (MLA)
Yu, Manrong…[et al.]. Antioxidant Function and Metabolomics Study in Mice after Dietary Supplementation with Methionine. BioMed Research International No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1138133
American Medical Association (AMA)
Yu, Manrong& Chen, Hui& Liu, Pan& Yang, Mei& Zou, Leqin& Xiao, Dingfu. Antioxidant Function and Metabolomics Study in Mice after Dietary Supplementation with Methionine. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1138133
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138133