Lateral Ramus Cortical Bone Plate in Alveolar Cleft Osteoplasty with Concomitant Use of Buccal Fat Pad Derived Cells and Autogenous Bone: Phase I Clinical Trial
Joint Authors
Soleimani, Masoud
Khojasteh, A.
Behnia, Hossein
Kheiri, Lida
Tehranchi, Azita
Nazeman, Pantea
Nadjmi, Nasser
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Tissue regeneration has become a promising treatment for craniomaxillofacial bone defects such as alveolar clefts.
This study sought to assess the efficacy of lateral ramus cortical plate with buccal fat pad derived mesenchymal stem cells (BFSCs) in treatment of human alveolar cleft defects.
Ten patients with unilateral anterior maxillary cleft met the inclusion criteria and were assigned to three treatment groups.
First group was treated with anterior iliac crest (AIC) bone and a collagen membrane (AIC group), the second group was treated with lateral ramus cortical bone plate (LRCP) with BFSCs mounted on a natural bovine bone mineral (LRCP+BFSC), and the third group was treated with AIC bone, BFSCs cultured on natural bovine bone mineral, and a collagen membrane (AIC+BFSC).
The amount of regenerated bone was measured using cone beam computed tomography 6 months postoperatively.
AIC group showed the least amount of new bone formation (70±10.40%).
LRCP+BFSC group demonstrated defect closure and higher amounts of new bone formation (75±3.5%) but less than AIC+BFSC (82.5±6.45%), suggesting that use of BFSCs within LRCP cage and AIC may enhance bone regeneration in alveolar cleft bone defects; however, the differences were not statistically significant.
This clinical trial was registered at clinicaltrial.gov with NCT02859025 identifier.
American Psychological Association (APA)
Khojasteh, A.& Kheiri, Lida& Behnia, Hossein& Tehranchi, Azita& Nazeman, Pantea& Nadjmi, Nasser…[et al.]. 2017. Lateral Ramus Cortical Bone Plate in Alveolar Cleft Osteoplasty with Concomitant Use of Buccal Fat Pad Derived Cells and Autogenous Bone: Phase I Clinical Trial. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138148
Modern Language Association (MLA)
Khojasteh, A.…[et al.]. Lateral Ramus Cortical Bone Plate in Alveolar Cleft Osteoplasty with Concomitant Use of Buccal Fat Pad Derived Cells and Autogenous Bone: Phase I Clinical Trial. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1138148
American Medical Association (AMA)
Khojasteh, A.& Kheiri, Lida& Behnia, Hossein& Tehranchi, Azita& Nazeman, Pantea& Nadjmi, Nasser…[et al.]. Lateral Ramus Cortical Bone Plate in Alveolar Cleft Osteoplasty with Concomitant Use of Buccal Fat Pad Derived Cells and Autogenous Bone: Phase I Clinical Trial. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138148
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138148