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Snake Venom PLA2, a Promising Target for Broad-Spectrum Antivenom Drug Development
Joint Authors
Xiao, Huixiang
Pan, Hong
Liao, Keren
Yang, Mengxue
Huang, Chunhong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Snakebite envenomation is a neglected global health problem, causing substantial mortality, disability, and psychological morbidity, especially in rural tropical and subtropical zones.
Antivenin is currently the only specific medicine for envenomation.
However, it is restricted by cold storage, snakebite diagnosis, and high price.
Snake venom phospholipase A2s (svPLA2s) are found in all kinds of venomous snake families (e.g., Viperidae, Elapidae, and Colubridae).
Along with their catalytic activity, svPLA2s elicit a wide variety of pharmacological effects that play a pivotal role in envenomation damage.
Hence, neutralization of the svPLA2s could weaken or inhibit toxic damage.
Here we overviewed the latest knowledge on the distribution, pathophysiological effects, and inhibitors of svPLA2s to elucidate the potential for a novel, wide spectrum antivenom drug targeting svPLA2s.
American Psychological Association (APA)
Xiao, Huixiang& Pan, Hong& Liao, Keren& Yang, Mengxue& Huang, Chunhong. 2017. Snake Venom PLA2, a Promising Target for Broad-Spectrum Antivenom Drug Development. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138159
Modern Language Association (MLA)
Xiao, Huixiang…[et al.]. Snake Venom PLA2, a Promising Target for Broad-Spectrum Antivenom Drug Development. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1138159
American Medical Association (AMA)
Xiao, Huixiang& Pan, Hong& Liao, Keren& Yang, Mengxue& Huang, Chunhong. Snake Venom PLA2, a Promising Target for Broad-Spectrum Antivenom Drug Development. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138159
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138159