The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer
Joint Authors
Wu, Hua-Tao
Chen, Wen-Jia
Xu, Ya
Shen, Jia-Xin
Chen, Wen-Tian
Liu, Jing
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
To investigate the expression patterns and prognostic values of STEAP family members in the occurrence and development of breast cancer.
Materials and Methods.
The Human Protein Atlas was used to analyze the expression level of STEAPs in human normal tissues and malignant tumors.
ONCOMINE datasets were analyzed for the comparison of the STEAPs levels between malignant cancers and corresponding normal tissues.
Kaplan-Meier plotter was used to analyze the prognostic value of STEAPs in breast cancer patients.
Results.
STEAPs were widely distributed in human normal tissues with diverse levels.
Normally, it is predicted that STEAP1 and STEAP2 were involved in the mineral absorption process, while STEAP3 participated in the TP53 signaling pathway and iron apoptosis.
The results from ONCOMINE showed downregulation of STEAP1, STEAP2, and STEAP4 in breast cancers.
Survival analysis revealed that breast cancer patients with high levels of STEAP1, STEAP2, and STEAP4 had a good prognosis, while those with low expression had high overall mortality.
Conclusion.
STEAP1, STEAP2, and STEAP4 are predicted to be the potential prognostic biomarkers for breast cancer patients, providing novel therapeutic strategies for them.
American Psychological Association (APA)
Wu, Hua-Tao& Chen, Wen-Jia& Xu, Ya& Shen, Jia-Xin& Chen, Wen-Tian& Liu, Jing. 2020. The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1138183
Modern Language Association (MLA)
Wu, Hua-Tao…[et al.]. The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1138183
American Medical Association (AMA)
Wu, Hua-Tao& Chen, Wen-Jia& Xu, Ya& Shen, Jia-Xin& Chen, Wen-Tian& Liu, Jing. The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1138183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138183