Melanomas and Dysplastic Nevi Differ in Epidermal CD1c+ Dendritic Cell Count
Joint Authors
Białas, Magdalena
Dyduch, Grzegorz
Tyrak, Katarzyna Ewa
Glajcar, Anna
Szpor, Joanna
Okoń, Krzysztof
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Dendritic cells could be involved in immune surveillance of highly immunogenic tumors such as melanoma.
Their role in the progression melanocytic nevi to melanoma is however a matter of controversy.
Methods.
The number of dendritic cells within epidermis, in peritumoral zone, and within the lesion was counted on slides immunohistochemically stained for CD1a, CD1c, DC-LAMP, and DC-SIGN in 21 of dysplastic nevi, 27 in situ melanomas, and 21 invasive melanomas.
Results.
We found a significant difference in the density of intraepidermal CD1c+ cells between the examined lesions; the mean CD1c cell count was 7.00/mm2 for invasive melanomas, 2.94 for in situ melanomas, and 13.35 for dysplastic nevi.
The differences between dysplastic nevi and melanoma in situ as well as between dysplastic nevi and invasive melanoma were significant.
There was no correlation in number of positively stained cells between epidermis and dermis.
We did not observe any intraepidermal DC-LAMP+ cells neither in melanoma in situ nor in invasive melanoma as well as any intraepidermal DC-SIGN+ cells in dysplastic nevi.
Conclusion.
It was shown that the number of dendritic cells differs between dysplastic nevi, in situ melanomas, and invasive melanomas.
This could eventually suggest their participation in the development of melanoma.
American Psychological Association (APA)
Dyduch, Grzegorz& Tyrak, Katarzyna Ewa& Glajcar, Anna& Szpor, Joanna& Białas, Magdalena& Okoń, Krzysztof. 2017. Melanomas and Dysplastic Nevi Differ in Epidermal CD1c+ Dendritic Cell Count. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138226
Modern Language Association (MLA)
Dyduch, Grzegorz…[et al.]. Melanomas and Dysplastic Nevi Differ in Epidermal CD1c+ Dendritic Cell Count. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1138226
American Medical Association (AMA)
Dyduch, Grzegorz& Tyrak, Katarzyna Ewa& Glajcar, Anna& Szpor, Joanna& Białas, Magdalena& Okoń, Krzysztof. Melanomas and Dysplastic Nevi Differ in Epidermal CD1c+ Dendritic Cell Count. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138226
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138226