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Safety Assessment of Water-Extract Sericin from Silkworm (Bombyx mori) Cocoons Using Different Model Approaches
Joint Authors
Zhao, Peng
He, Li
Liang, Huili
Wang, Yanwu
Yang, Hui
Qin, Huiyan
Zhang, Jiehong
Yao, Siyu
Chen, Huafeng
Qin, Guangqiu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Sericin is a natural protein component of silks of silkworm and has potential utility in multiple areas such as pharmacological, cosmetics, and biotechnological industries.
However, the understanding of its toxicological safety is still limited.
This study evaluated the safety of water-extract sericin from silkworm (Bombyx mori) cocoons using different model approaches, including three genotoxicity studies (the bacterial reverse mutation test, the mammalian erythrocyte micronucleus test, and the mouse spermatogonia chromosomal aberration test) and a 90-day subchronic toxicity study in Sprague-Dawley (SD) rats.
The results of this study showed that water-extract sericin was nonmutagenic and nongenotoxic both in vitro and in vivo.
Sericin did not induce significant changes in the body and organ weight, food intake, blood hematology and serum biochemistry, urine index, and histopathology in rats.
The NOAEL of sericin was determined to be 1 g/kg/day for male and female rats.
These results indicated that water-extract sericin was of low toxicity in the experimental conditions of the current study and had the potential for application in food-related products.
American Psychological Association (APA)
Qin, Huiyan& Zhang, Jiehong& Yang, Hui& Yao, Siyu& He, Li& Liang, Huili…[et al.]. 2020. Safety Assessment of Water-Extract Sericin from Silkworm (Bombyx mori) Cocoons Using Different Model Approaches. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1138233
Modern Language Association (MLA)
Qin, Huiyan…[et al.]. Safety Assessment of Water-Extract Sericin from Silkworm (Bombyx mori) Cocoons Using Different Model Approaches. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1138233
American Medical Association (AMA)
Qin, Huiyan& Zhang, Jiehong& Yang, Hui& Yao, Siyu& He, Li& Liang, Huili…[et al.]. Safety Assessment of Water-Extract Sericin from Silkworm (Bombyx mori) Cocoons Using Different Model Approaches. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1138233
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138233