Hepatic Immune Microenvironment in Alcoholic and Nonalcoholic Liver Disease
Joint Authors
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Many types of innate (natural killer cells, natural killer T cells, and Kupffer cells/macrophages) and adaptive (T cells and B cells) immune cells are enriched within the liver and function in liver physiology and pathology.
Liver pathology is generally induced by two types of immunologic insults: failure to eliminate antigens derived from the gastrointestinal tract which are important for host defense and an impaired tissue protective tolerance mechanism that helps reduce the negative outcomes of immunopathology.
Accumulating evidence from the last several decades suggests that hepatic immune cells play an important role in the pathogenesis of alcoholic and nonalcoholic liver injury and inflammation in humans and mice.
Here, we focus on the roles of innate and adaptive immune cells in the development and maintenance of alcoholic liver disease and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Additionally, the pathogenesis of liver disease and new therapeutic targets for preventing and treating alcoholic liver disease and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis are discussed.
American Psychological Association (APA)
Byun, Jin-Seok& Yi, Hyon-Seung. 2017. Hepatic Immune Microenvironment in Alcoholic and Nonalcoholic Liver Disease. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138252
Modern Language Association (MLA)
Byun, Jin-Seok& Yi, Hyon-Seung. Hepatic Immune Microenvironment in Alcoholic and Nonalcoholic Liver Disease. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1138252
American Medical Association (AMA)
Byun, Jin-Seok& Yi, Hyon-Seung. Hepatic Immune Microenvironment in Alcoholic and Nonalcoholic Liver Disease. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138252
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138252