A Randomized Controlled Trial Evaluating the Effects of Diosmin in the Treatment of Radicular Pain
Joint Authors
Wang, Yinhe
Cao, Yang
Fang, Xin
Ye, Lei
Li, Yishan
Shi, Hongfei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Diosmin has been widely used to treat patients with vascular pain for its potent anti-inflammatory and analgesic effects.
To evaluate the therapeutic effects of Diosmin in the treatment of radicular pain, we conducted an investigator-initiated, randomized, active-controlled noninferiority trial between January 1, 2009, and December 1, 2010.
Diosmin (50 mg/kg/day) was orally administered to treat the radicular pain in 150 patients for one month.
Another 150 patients with the same symptom were given 20% 250 ml mannitol (1 g/kg/day) for 7 days and dexamethasone (10 mg/day) for 3 days intravenously guttae.
Short-term relief and long-term relief were measured.
Secondary outcomes include improvement in functional and psychological status, return to work, and reduction in anti-inflammatory analgesic drugs intake.
Patients treated with oral Diosmin achieved reduction in radicular pain.
The total satisfaction rate of Diosmin group was 84.7% [95% confidence interval (CI): 77.9%, 90.0%], and the complete satisfaction rate was 50.7% (95% CI: 42.4%, 58.9%).
No statistically significant difference was found between the Diosmin group and the active-control group regarding patient satisfaction.
No adverse effects were found during the study period.
Our study suggests that clinical application of Diosmin with a dose of 50 mg/kg/day might reduce the radicular pain.
This trial is registered with ISRCTN97157037.
American Psychological Association (APA)
Wang, Yinhe& Fang, Xin& Ye, Lei& Li, Yishan& Shi, Hongfei& Cao, Yang. 2017. A Randomized Controlled Trial Evaluating the Effects of Diosmin in the Treatment of Radicular Pain. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138257
Modern Language Association (MLA)
Wang, Yinhe…[et al.]. A Randomized Controlled Trial Evaluating the Effects of Diosmin in the Treatment of Radicular Pain. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1138257
American Medical Association (AMA)
Wang, Yinhe& Fang, Xin& Ye, Lei& Li, Yishan& Shi, Hongfei& Cao, Yang. A Randomized Controlled Trial Evaluating the Effects of Diosmin in the Treatment of Radicular Pain. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138257
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138257