Histological and Pathological Assessment of miR-204 and SOX4 Levels in Gastric Cancer Patients
Joint Authors
Yuan, Xiao
Wang, Shuanhu
Liu, Mulin
Lu, Zhen
Zhan, Yanqing
Wang, Wenbin
Xu, A-Man
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Gastric cancer is one of the most common cancers and the efficient therapeutic methods are limited.
Further study of the exact molecular mechanism of gastric cancer to develop novel targeted therapies is necessary and urgent.
We herein systematically examined that miR-204 suppressed both proliferation and metastasis of gastric cancer AGS cells.
miR-204 directly targeted SOX4.
In clinical tissue research, we determined that miR-204 was expressed much lower and SOX4 expressed much higher in gastric cancer tissues compared with normal gastric tissues.
Associated analysis with clinicopathological parameters in gastric cancer patients showed miR-204 was associated with no lymph node metastasis and early tumor stages whereas SOX4 was associated with lymph node metastasis and advanced tumor stages.
In addition, miR-204 and SOX4 were negatively correlated in tissues from gastric cancer patients.
Our findings examined the important role of miR-204 and SOX4 played in gastric cancer, and they could be used as candidate therapeutic targets for gastric cancer therapy.
American Psychological Association (APA)
Yuan, Xiao& Wang, Shuanhu& Liu, Mulin& Lu, Zhen& Zhan, Yanqing& Wang, Wenbin…[et al.]. 2017. Histological and Pathological Assessment of miR-204 and SOX4 Levels in Gastric Cancer Patients. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138267
Modern Language Association (MLA)
Yuan, Xiao…[et al.]. Histological and Pathological Assessment of miR-204 and SOX4 Levels in Gastric Cancer Patients. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1138267
American Medical Association (AMA)
Yuan, Xiao& Wang, Shuanhu& Liu, Mulin& Lu, Zhen& Zhan, Yanqing& Wang, Wenbin…[et al.]. Histological and Pathological Assessment of miR-204 and SOX4 Levels in Gastric Cancer Patients. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138267
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138267