Impact of Different Levels of iPTH on All-Cause Mortality in Dialysis Patients with Secondary Hyperparathyroidism after Parathyroidectomy
Joint Authors
Xie, Xisheng
Xi, Qiu Ping
Zhang, Ling
Zhang, Rui
Xiao, Yue Fei
Jin, Cheng Gang
Li, Yan Bo
Wang, Lin
Zhang, Xiao Xuan
Du, Shu Tong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Secondary hyperparathyroidism (SHPT) usually required parathyroidectomy (PTX) when drugs treatment is invalid.
Analysis was done on the impact of different intact parathyroid hormone (iPTH) after the PTX on all-cause mortality.
Methods.
An open, retrospective, multicenter cohort design was conducted.
The sample included 525 dialysis patients with SHPT who had undergone PTX.
Results.
404 patients conformed to the standard, with 36 (8.91%) deaths during the 11 years of follow-up.
One week postoperatively, different levels of serum iPTH were divided into four groups: A: ≤20 pg/mL; B: 21–150 pg/mL; C: 151–600 pg/mL; and D: >600 pg/mL.
All-cause mortality in groups with different iPTH levels appeared as follows: A (8.29%), B (3.54%), C (10.91%), and D (29.03%).
The all-cause mortality of B was the lowest, with D the highest.
We used group A as reference (hazard ratio (HR) = 1) compared with the other groups, and HRs on groups B, C, and D appeared as 0.57, 1.43, and 3.45, respectively.
Conclusion.
The all-cause mortality was associated with different levels of iPTH after the PTX.
We found that iPTH > 600 pg/mL appeared as a factor which increased the risk of all-cause mortality.
When iPTH levels were positively and effectively reducing, the risk of all-cause mortality also decreased.
The most appropriate level of postoperative iPTH seemed to be 21–150 pg/mL.
American Psychological Association (APA)
Xi, Qiu Ping& Xie, Xisheng& Zhang, Ling& Zhang, Rui& Xiao, Yue Fei& Jin, Cheng Gang…[et al.]. 2017. Impact of Different Levels of iPTH on All-Cause Mortality in Dialysis Patients with Secondary Hyperparathyroidism after Parathyroidectomy. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138289
Modern Language Association (MLA)
Xi, Qiu Ping…[et al.]. Impact of Different Levels of iPTH on All-Cause Mortality in Dialysis Patients with Secondary Hyperparathyroidism after Parathyroidectomy. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1138289
American Medical Association (AMA)
Xi, Qiu Ping& Xie, Xisheng& Zhang, Ling& Zhang, Rui& Xiao, Yue Fei& Jin, Cheng Gang…[et al.]. Impact of Different Levels of iPTH on All-Cause Mortality in Dialysis Patients with Secondary Hyperparathyroidism after Parathyroidectomy. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138289