Overexpression of MicroRNA-122 Resists Oxidative Stress-Induced Human Umbilical Vascular Endothelial Cell Injury by Inhibition of p53
Joint Authors
Li, Hua-qing
Pan, Zhi-yu
Yang, Zhen
Zhang, Don-bing
Chen, Qian
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Deep venous thrombosis (DVT) constitutes a great threat to health worldwide.
Endothelial cell injury and dysfunction comprise the critical contributor for the development of DVT.
However, the mechanism behind it remains poorly elucidated.
The study is aimed at investigating the role of microRNA-122 (miR-122) and oxidative stress on DVT.
The results showed that miR-122 overexpression dampened H2O2-evoked cytotoxic injury in human umbilical vein endothelial cells (HUVECs) by increasing cell viability, suppressing cell apoptosis and oxidative stress injury.
Notably, miR-122 overexpression attenuated provasoconstriction factor endothelin-1 (ET-1) expression in HUVECs exposed to H2O2 but enhanced the productions of vasodilatation factor Prostaglandin F1α (PGF1α).
Moreover, inhibition of miR-122 had the opposite results.
miR-122 could inhibit the expression of p53.
Low expression of p53 could enhance the protection of miR-122 on HUVEC injury.
This study highlights that miR-122 overexpression may restore H2O2-induced HUVEC injury by regulating the expression of p53.
American Psychological Association (APA)
Li, Hua-qing& Pan, Zhi-yu& Yang, Zhen& Zhang, Don-bing& Chen, Qian. 2020. Overexpression of MicroRNA-122 Resists Oxidative Stress-Induced Human Umbilical Vascular Endothelial Cell Injury by Inhibition of p53. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1138297
Modern Language Association (MLA)
Li, Hua-qing…[et al.]. Overexpression of MicroRNA-122 Resists Oxidative Stress-Induced Human Umbilical Vascular Endothelial Cell Injury by Inhibition of p53. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1138297
American Medical Association (AMA)
Li, Hua-qing& Pan, Zhi-yu& Yang, Zhen& Zhang, Don-bing& Chen, Qian. Overexpression of MicroRNA-122 Resists Oxidative Stress-Induced Human Umbilical Vascular Endothelial Cell Injury by Inhibition of p53. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1138297
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138297