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Nonsurgical Treatment for Vocal Fold Leukoplakia: An Analysis of 178 Cases
Joint Authors
Wu, Haitao
Chen, Min
Cheng, Lei
Li, Chang-jiang
Chen, Jian
Shu, Yi-lai
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To assess the effectiveness and identify vocal fold leukoplakia types appropriate for nonsurgical treatment.
Methods.
The vocal fold leukoplakia in 178 patients was divided by gross appearance into three subtypes: flat and smooth, elevated and smooth, and rough.
All patients received nonsurgical treatment including smoking and drinking cessation, voice rest, omeprazole, and Chinese medication therapy.
The clinical response of three subtypes was assessed after a 6-month follow-up.
Results.
Vocal fold leukoplakia subtypes included flat and smooth (n=66; 37.1%), elevated and smooth (n=103; 57.9%), and rough (n=9; 5.0%).
The rate of complete response was 80.3%, 66.0%, and 0.0% for the 3 lesion types, respectively (rough versus flat and smooth, P<0.001; rough versus elevated and smooth, P<0.001, Fisher’s exact test).
The incidence of carcinoma in rough leukoplakia was significantly higher than that in smooth leukoplakia (44.4% versus 2.4%, P=0.002, Fisher’s exact test).
Clinical type was the only significant factor for clinical response of nonsurgical treatment (P=0.005, ordinal logistic regression).
Conclusions.
The effectiveness of nonsurgical treatment for smooth vocal fold leukoplakia is better in comparison to rough vocal fold leukoplakia.
Smooth leukoplakia could be managed with nonsurgical treatment; more aggressive treatments should be considered for rough leukoplakia.
American Psychological Association (APA)
Chen, Min& Cheng, Lei& Li, Chang-jiang& Chen, Jian& Shu, Yi-lai& Wu, Haitao. 2017. Nonsurgical Treatment for Vocal Fold Leukoplakia: An Analysis of 178 Cases. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138307
Modern Language Association (MLA)
Chen, Min…[et al.]. Nonsurgical Treatment for Vocal Fold Leukoplakia: An Analysis of 178 Cases. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1138307
American Medical Association (AMA)
Chen, Min& Cheng, Lei& Li, Chang-jiang& Chen, Jian& Shu, Yi-lai& Wu, Haitao. Nonsurgical Treatment for Vocal Fold Leukoplakia: An Analysis of 178 Cases. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138307
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138307