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Follicular Fluid Metabolite Changes in Dairy Cows with Inactive Ovary Identified Using Untargeted Metabolomics
Joint Authors
Xu, Chuang
Bai, YunLong
Zhang, HongYou
Xia, Cheng
Wu, Ling
Zhang, Feng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The metabolism of dairy cows with inactive ovaries differs from that of healthy dairy cows.
However, the molecular mechanisms underpinning these physiological and metabolic changes remain unclear.
The purpose of this study was to investigate follicular fluid metabolite changes in dairy cows with inactive ovaries.
Untargeted metabolomics technology and multivariate statistical analysis were used to screen differential metabolites in follicular fluid samples between inactive ovaries and estrus cows at 45-60 d postpartum.
Fourteen differential metabolites were identified, consisting of amino acids, lipids, sugars, and nucleotides.
When compared with healthy animal samples, eight follicular fluid metabolites were significantly increased, and six metabolites were significantly decreased in dairy cows with inactive ovaries.
Metabolic pathway analyses indicated that differential metabolites were primarily involved in glycerol phospholipid metabolism, arachidonic acid metabolism, valine, leucine and isoleucine biosynthesis, and phenylalanine metabolism.
These metabolites and their enrichment pathways indicate that the enhancement of lipid metabolism and the weakening of carbohydrate production of amino acids in dairy cows with impaired follicular development.
Overall, these data provide a better understanding of the changes that could affect follicular development during the postpartum period and lay the ground for further investigations.
American Psychological Association (APA)
Bai, YunLong& Zhang, Feng& Zhang, HongYou& Xu, Chuang& Wu, Ling& Xia, Cheng. 2020. Follicular Fluid Metabolite Changes in Dairy Cows with Inactive Ovary Identified Using Untargeted Metabolomics. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138317
Modern Language Association (MLA)
Bai, YunLong…[et al.]. Follicular Fluid Metabolite Changes in Dairy Cows with Inactive Ovary Identified Using Untargeted Metabolomics. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1138317
American Medical Association (AMA)
Bai, YunLong& Zhang, Feng& Zhang, HongYou& Xu, Chuang& Wu, Ling& Xia, Cheng. Follicular Fluid Metabolite Changes in Dairy Cows with Inactive Ovary Identified Using Untargeted Metabolomics. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138317
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138317