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mTOR-Dependent Cell Proliferation in the Brain
Joint Authors
Biagioni, Francesca
Fornai, Francesco
Frati, Alessandro
Gambardella, Stefano
Ryskalin, Larisa
Lazzeri, Gloria
Flaibani, Marina
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-13
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The mammalian Target of Rapamycin (mTOR) is a molecular complex equipped with kinase activity which controls cell viability being key in the PI3K/PTEN/Akt pathway.
mTOR acts by integrating a number of environmental stimuli to regulate cell growth, proliferation, autophagy, and protein synthesis.
These effects are based on the modulation of different metabolic pathways.
Upregulation of mTOR associates with various pathological conditions, such as obesity, neurodegeneration, and brain tumors.
This is the case of high-grade gliomas with a high propensity to proliferation and tissue invasion.
Glioblastoma Multiforme (GBM) is a WHO grade IV malignant, aggressive, and lethal glioma.
To date, a few treatments are available although the outcome of GBM patients remains poor.
Experimental and pathological findings suggest that mTOR upregulation plays a major role in determining an aggressive phenotype, thus determining relapse and chemoresistance.
Among several activities, mTOR-induced autophagy suppression is key in GBM malignancy.
In this article, we discuss recent evidence about mTOR signaling and its role in normal brain development and pathological conditions, with a special emphasis on its role in GBM.
American Psychological Association (APA)
Ryskalin, Larisa& Lazzeri, Gloria& Flaibani, Marina& Biagioni, Francesca& Gambardella, Stefano& Frati, Alessandro…[et al.]. 2017. mTOR-Dependent Cell Proliferation in the Brain. BioMed Research International،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1138356
Modern Language Association (MLA)
Ryskalin, Larisa…[et al.]. mTOR-Dependent Cell Proliferation in the Brain. BioMed Research International No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1138356
American Medical Association (AMA)
Ryskalin, Larisa& Lazzeri, Gloria& Flaibani, Marina& Biagioni, Francesca& Gambardella, Stefano& Frati, Alessandro…[et al.]. mTOR-Dependent Cell Proliferation in the Brain. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1138356
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138356