“Olfactory Three-Needle” Enhances Spatial Learning and Memory Ability in SAMP8 Mice
Joint Authors
Gao, Xin-Yan
Wang, Yuan
Wang, Qiang
Ren, Bo
Guo, Ting
Qiang, Jing
Cao, Hui
Gao, Yujie
Liu, Zhibin
Zhu, Bing
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
As one of the most important therapies in complementary and alternative medicine, acupuncture has been used in the treatment of Alzheimer’s disease (AD).
Acupuncture of “olfactory three-needle” manipulation can improve the cognitive ability of AD patients.
However, the mechanism of “olfactory three-needle” in AD remains largely unknown.
Here, we identified that the “olfactory three-needle” therapy and eugenol olfactory stimulation both reduced the deposition of β-amyloid (Aβ) protein and increased the expression of synaptophysin (SYP), but only the “olfactory three-needle” enhanced the spatial learning and memory ability of SAMP8.
Remarkably, the “olfactory three-needle” inhibited the phosphorylation of p38MAPK and the excessive activation of microglia (MG) in the hippocampus.
Our study demonstrates that the “olfactory three-needle” enhances spatial learning and memory ability by inhibiting the phosphorylation of p38MAPK and the excessive activation of MG to reduce the neuroinflammatory response and neurotoxicity of Aβ and promote synaptic regeneration, but it was not completely consistent with the stimulation of the olfactory system.
American Psychological Association (APA)
Wang, Yuan& Wang, Qiang& Ren, Bo& Guo, Ting& Qiang, Jing& Cao, Hui…[et al.]. 2020. “Olfactory Three-Needle” Enhances Spatial Learning and Memory Ability in SAMP8 Mice. Behavioural Neurology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1138378
Modern Language Association (MLA)
Wang, Yuan…[et al.]. “Olfactory Three-Needle” Enhances Spatial Learning and Memory Ability in SAMP8 Mice. Behavioural Neurology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1138378
American Medical Association (AMA)
Wang, Yuan& Wang, Qiang& Ren, Bo& Guo, Ting& Qiang, Jing& Cao, Hui…[et al.]. “Olfactory Three-Needle” Enhances Spatial Learning and Memory Ability in SAMP8 Mice. Behavioural Neurology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1138378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138378