Candidate Gene Identification of Feed Efficiency and Coat Color Traits in a C57BL6J × Kunming F2 Mice Population Using Genome-Wide Association Study
Joint Authors
Li, Xinyun
Miao, Yuanxin
Soudy, Fathia
Xu, Zhong
Liao, Mingxing
Zhao, Shuhong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Feed efficiency (FE) is a very important trait in livestock industry.
Identification of the candidate genes could be of benefit for the improvement of FE trait.
Mouse is used as the model for many studies in mammals.
In this study, the candidate genes related to FE and coat color were identified using C57BL/6J (C57) × Kunming (KM) F2 mouse population.
GWAS results showed that 61 and 2 SNPs were genome-wise suggestive significantly associated with feed conversion ratio (FCR) and feed intake (FI) traits, respectively.
Moreover, the Erbin, Msrb2, Ptf1a, and Fgf10 were considered as the candidate genes of FE.
The Lpl was considered as the candidate gene of FI.
Further, the coat color trait was studied.
KM mice are white and C57 ones are black.
The GWAS results showed that the most significant SNP was located at chromosome 7, and the closely linked gene was Tyr.
Therefore, our study offered useful target genes related to FE in mice; these genes may play similar roles in FE of livestock.
Also, we identified the major gene of coat color in mice, which would be useful for better understanding of natural mutation of the coat color in mice.
American Psychological Association (APA)
Miao, Yuanxin& Soudy, Fathia& Xu, Zhong& Liao, Mingxing& Zhao, Shuhong& Li, Xinyun. 2017. Candidate Gene Identification of Feed Efficiency and Coat Color Traits in a C57BL6J × Kunming F2 Mice Population Using Genome-Wide Association Study. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138382
Modern Language Association (MLA)
Xu, Zhong…[et al.]. Candidate Gene Identification of Feed Efficiency and Coat Color Traits in a C57BL6J × Kunming F2 Mice Population Using Genome-Wide Association Study. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1138382
American Medical Association (AMA)
Miao, Yuanxin& Soudy, Fathia& Xu, Zhong& Liao, Mingxing& Zhao, Shuhong& Li, Xinyun. Candidate Gene Identification of Feed Efficiency and Coat Color Traits in a C57BL6J × Kunming F2 Mice Population Using Genome-Wide Association Study. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138382
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138382