Rutin via Increase in the CA3 Diameter of the Hippocampus Exerted Antidepressant-Like Effect in Mouse Model of Maternal Separation Stress: Possible Involvement of NMDA Receptors
Joint Authors
Anjomshoa, Maryam
Boroujeni, Shakiba Nasiri
Ghasemi, Sorayya
Lorigooini, Zahra
Amiri, Ahmad
Balali-dehkordi, Shima
Amini-khoei, Hossein
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background and Aim.
Rutin is a flavonol with neuroprotective activity.
The aim of the present study is to investigate the role of the glutamatergic system in the antidepressant-like effect of rutin in a mouse model of maternal separation (MS) stress focusing on histological changes in the CA3 area of the hippocampus.
Methods.
Mouse neonates were exposed to MS paradigm 3 hours daily from postnatal days (PND) 2 to 14.
The control and MS mice were divided separately into 16 groups (n=8) (8 groups for each set) including mice that received normal saline, mice that received rutin at doses of 10, 50, and 100 mg/kg, mice that received NMDA at a dose of 150 mg/kg, mice that received ketamine (NMDA antagonist) at a dose of 0.25 mg/kg, mice that received NMDA antagonist plus a subeffective dose of rutin, and mice that received NMDA plus an effective dose of rutin.
Forced swimming test (FST) was performed.
Afterwards, the hippocampus was evaluated in cases of histopathological changes as well as expression of NR2A and NR2B genes.
Results.
Rutin significantly reduced immobility time in the FST.
The expression of NR2A and NR2B subunits of NMDA receptor in MS mice was significantly higher than that in the control group.
Rutin significantly decreased the expression of NR2B and NR2A subunits in the hippocampus.
The CA3 diameter and percentage of dark neurons in the hippocampus of MS mice significantly decreased and increased, respectively, which partially reversed following rutin administration.
Conclusion.
Rutin, partially, through a neuroprotective effect on the hippocampus exerted antidepressant-like effect.
We concluded that NMDA receptors, at least in part, mediated the beneficial effect of rutin.
American Psychological Association (APA)
Anjomshoa, Maryam& Boroujeni, Shakiba Nasiri& Ghasemi, Sorayya& Lorigooini, Zahra& Amiri, Ahmad& Balali-dehkordi, Shima…[et al.]. 2020. Rutin via Increase in the CA3 Diameter of the Hippocampus Exerted Antidepressant-Like Effect in Mouse Model of Maternal Separation Stress: Possible Involvement of NMDA Receptors. Behavioural Neurology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138394
Modern Language Association (MLA)
Anjomshoa, Maryam…[et al.]. Rutin via Increase in the CA3 Diameter of the Hippocampus Exerted Antidepressant-Like Effect in Mouse Model of Maternal Separation Stress: Possible Involvement of NMDA Receptors. Behavioural Neurology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1138394
American Medical Association (AMA)
Anjomshoa, Maryam& Boroujeni, Shakiba Nasiri& Ghasemi, Sorayya& Lorigooini, Zahra& Amiri, Ahmad& Balali-dehkordi, Shima…[et al.]. Rutin via Increase in the CA3 Diameter of the Hippocampus Exerted Antidepressant-Like Effect in Mouse Model of Maternal Separation Stress: Possible Involvement of NMDA Receptors. Behavioural Neurology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138394