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Facial Emotion Recognition and Polymorphisms of Dopaminergic Pathway Genes in Children with ASD
Joint Authors
Liu, Zhuo
Liu, Jun
Zhang, Zengyu
Hu, Fengpei
Yu, Hong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
It is inconclusive whether children with autism spectrum disorder (ASD) experience a deficit in facial emotion recognition.
The dopaminergic pathway has been implicated in the pathogenesis of ASD.
This study was aimed at determining facial emotion recognition and its correlation with polymorphisms in the dopaminergic pathway genes in children with ASD.
Methods.
Facial emotion recognition was examined in 98 children with ASD and 60 age- and gender-matched healthy controls.
The severity of ASD was evaluated using the Childhood Autism Rating Scale (CARS).
DNA from blood cells was used to analyze the genotypes of single-nucleotide polymorphisms (SNPs) in dopaminergic pathway genes.
SNPs of DBH rs1611115, DDC rs6592961, DRD1 rs251937, DRD2 rs4630328, and DRD3 rs167771 were analyzed.
Results.
Children with ASD took a significantly longer time to recognize all facial emotions, and their interpretations were less accurate for anger at low intensity and fear at both low and high intensities.
The severity of the disease was associated with significant delays in recognition of all facial emotions and with a decrease in accuracy in recognition of happiness and anger at low intensity.
Accuracy in recognizing fear at high intensity and sadness at low intensity was associated with rs251937 and rs4630328, respectively, in children with ASD.
Multivariate logistic regression analysis revealed that SNP rs167771, response time for the recognition of happiness, sadness and fear, and accuracy in recognition of anger and fear were all associated with the risk of childhood ASD.
Conclusions.
Children with ASD experience a deficit in facial emotion recognition.
Certain SNPs in the dopaminergic pathway genes are associated with accuracy in recognizing selective facial emotions in children with ASD.
American Psychological Association (APA)
Liu, Zhuo& Liu, Jun& Zhang, Zengyu& Yu, Hong& Hu, Fengpei. 2020. Facial Emotion Recognition and Polymorphisms of Dopaminergic Pathway Genes in Children with ASD. Behavioural Neurology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1138406
Modern Language Association (MLA)
Liu, Zhuo…[et al.]. Facial Emotion Recognition and Polymorphisms of Dopaminergic Pathway Genes in Children with ASD. Behavioural Neurology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1138406
American Medical Association (AMA)
Liu, Zhuo& Liu, Jun& Zhang, Zengyu& Yu, Hong& Hu, Fengpei. Facial Emotion Recognition and Polymorphisms of Dopaminergic Pathway Genes in Children with ASD. Behavioural Neurology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1138406
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138406