Zoledronic Acid Regulates Autophagy and Induces Apoptosis in Colon Cancer Cell Line CT26
Joint Authors
Zhu, Jinhua
Liu, Meihui
Liu, Yuanfen
Zhang, Yiting
Yang, Bing
Zhang, Wei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Zoledronic acid (ZOL) is the third generation of bisphosphonates, which can inhibit many tumors growth, especially to inhibit the growth of colon cancer.
However, the molecular mechanism is still very mysterious.
In this study, we observed that ZOL could regulate CT26 colon cancer cells autophagy, promote CT26 cells apoptosis, and inhibit CT26 cells proliferation.
Western blotting analysis showed that proapoptosis protein caspase-3 was basically unchanged, whereas the expression of the activated caspase-3 was significantly increased, after CT26 cells were treated with different doses of zoledronic acid.
Western blot also showed that ZOL could significantly affect the expression of p-p53 and autophagy-related proteins beclin-1 and p62.
In conclusion, the antitumor effect of ZOL on CT26 colon cancer cells in vitro is achieved by apoptosis induction and autophagy regulation, resulting in inhibition of cell proliferation.
American Psychological Association (APA)
Zhu, Jinhua& Liu, Meihui& Liu, Yuanfen& Zhang, Yiting& Yang, Bing& Zhang, Wei. 2017. Zoledronic Acid Regulates Autophagy and Induces Apoptosis in Colon Cancer Cell Line CT26. BioMed Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1138445
Modern Language Association (MLA)
Zhu, Jinhua…[et al.]. Zoledronic Acid Regulates Autophagy and Induces Apoptosis in Colon Cancer Cell Line CT26. BioMed Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1138445
American Medical Association (AMA)
Zhu, Jinhua& Liu, Meihui& Liu, Yuanfen& Zhang, Yiting& Yang, Bing& Zhang, Wei. Zoledronic Acid Regulates Autophagy and Induces Apoptosis in Colon Cancer Cell Line CT26. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1138445
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138445