The Efficacy of Pegylated Liposomal Doxorubicin-Based Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Case-Control Study in Taiwan
Joint Authors
Hung, Chih-Chiang
Yang, Youngsen
Tsai, I-Chen
Hsu, Chiann-yi
Liu, Chia-Hua
Yang, Jie-Ru
Source
Biochemistry Research International
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Breast cancer is a global issue regarding women’s health, and high incident rates remain in the Taiwanese female population.
Chemotherapy, using anthracycline-based chemotherapeutic agents in neoadjuvant settings, has been introduced as a promising new therapeutic option for treatment of invasive breast cancer.
Set apart from conventional anthracycline regimens such as epirubicin, pegylated liposomal doxorubicin (Lipo-Dox®, PLD) was introduced for providing a justifiable treatment effect, while offering a favorable toxicity profile for breast cancer patients in a metastatic setting.
However, the efficacy of PLD in neoadjuvant settings for breast cancer patients has not yet been sufficiently reported.
This study aims to investigate the efficacy of PLD-based neoadjuvant chemotherapy in breast cancer patients using a retrospective matched case-control study.
A total of 183 PLD cases and 183 epirubicin-based controls were included after a 1 : 1 ratio case-control matching procedure was held, according to the matching criteria.
These criteria included the patient’s preoperative clinical stage, molecular subtype, chemotherapy regimen with taxanes prior to surgery, and histological grade.
All data were collected according to an institutional review board approved protocol.
The study results reported that the PLD and epirubicin groups both obtained similar outcomes in pathologic complete response (pCR), recurrence, and overall survival rate with no statistically significant differences.
Overall, the study results demonstrate that PLD-based neoadjuvant chemotherapy offers a similar effect of treatment with a favorable toxicity profile within the study follow-up duration, when compared with conventional epirubicin-based neoadjuvant chemotherapy.
American Psychological Association (APA)
Hung, Chih-Chiang& Yang, Youngsen& Tsai, I-Chen& Hsu, Chiann-yi& Liu, Chia-Hua& Yang, Jie-Ru. 2020. The Efficacy of Pegylated Liposomal Doxorubicin-Based Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Case-Control Study in Taiwan. Biochemistry Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138456
Modern Language Association (MLA)
Hung, Chih-Chiang…[et al.]. The Efficacy of Pegylated Liposomal Doxorubicin-Based Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Case-Control Study in Taiwan. Biochemistry Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1138456
American Medical Association (AMA)
Hung, Chih-Chiang& Yang, Youngsen& Tsai, I-Chen& Hsu, Chiann-yi& Liu, Chia-Hua& Yang, Jie-Ru. The Efficacy of Pegylated Liposomal Doxorubicin-Based Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Case-Control Study in Taiwan. Biochemistry Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138456
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138456