Phenolic Content, Antioxidant Activity, Anti-Inflammatory Potential, and Acute Toxicity Study of Thymus leptobotrys Murb. Extracts
Joint Authors
Alaoui, Katim
Oubihi, Asmaa
Hosni, Hanae
Nounah, Issmail
Ettouil, Abdessamad
Harhar, Hicham
Ouhssine, Mohammed
Guessous, Zineb
Source
Biochemistry Research International
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Thymus leptobotrys is a medicinal plant belonging to the Lamiaceae family, endemic in Morocco, and used in traditional medicine.
The present work aims to study the phenolic compounds, the antioxidant activity, the anti-inflammatory effect, and the toxicity of two ethanolic and methanolic extracts of Thymus leptobotrys aerial part.
The yield of the methanolic extraction (22.2%) is higher than that of the ethanolic extraction (15.8%) and is characterized by higher contents of polyphenols 243.08 mg/g GAE (mg/g of gallic acid), flavonoids 179.28 mg/g RE (mg/g of rutin), and tannins 39.31 mg/g CE (mg/g of catechin).
The in vitro measurement of antioxidant activity with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical reduction test and Trolox equivalent antioxidant capacity (TEAC) test demonstrates the higher performance of the methanolic extract.
The evaluation of the anti-inflammatory effect in vivo on adult Wistar female rats leads to a very significant decrease in the inflammation of the edema compared to the standard drug (indomethacin) and the control group.
The toxicity test reveals that both extracts showed no toxicity within an LD50 above 2000 mg/kg body weight of the rats.
American Psychological Association (APA)
Oubihi, Asmaa& Hosni, Hanae& Nounah, Issmail& Ettouil, Abdessamad& Harhar, Hicham& Alaoui, Katim…[et al.]. 2020. Phenolic Content, Antioxidant Activity, Anti-Inflammatory Potential, and Acute Toxicity Study of Thymus leptobotrys Murb. Extracts. Biochemistry Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1138472
Modern Language Association (MLA)
Oubihi, Asmaa…[et al.]. Phenolic Content, Antioxidant Activity, Anti-Inflammatory Potential, and Acute Toxicity Study of Thymus leptobotrys Murb. Extracts. Biochemistry Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1138472
American Medical Association (AMA)
Oubihi, Asmaa& Hosni, Hanae& Nounah, Issmail& Ettouil, Abdessamad& Harhar, Hicham& Alaoui, Katim…[et al.]. Phenolic Content, Antioxidant Activity, Anti-Inflammatory Potential, and Acute Toxicity Study of Thymus leptobotrys Murb. Extracts. Biochemistry Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1138472
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138472