Single-Nucleotide Polymorphisms in XPO5 are Associated with Noise-Induced Hearing Loss in a Chinese Population
Joint Authors
Zhang, Juan
Wang, Boshen
Han, Lei
Wang, Ning
Zhu, Baoli
Guo, Jiadi
Zhang, Suhao
Source
Biochemistry Research International
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.The purpose of this study was to investigate the correlation between single-nucleotide polymorphism (SNP) in 3′UTR of XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5 gene.
Methods.We conducted a case-control study involving 1040 cases and 1060 controls.
The effects of SNPs on XPO5 expression were studied by genotyping, real-time polymerase chain reaction (qPCR), cell transfection, and the dual-luciferase reporter assay.
Results.We genotyped four SNPs (rs2257082, rs11077, rs7755135, and rs1106841) in the XPO5 gene.
The rs2257082 AG/GG carriers have special connection to an increased risk of noise-induced hearing loss compared to the AA carriers.
The rs11077TG/GG carriers had a significantly increased association with NIHL susceptibility than the TT carriers.
There was a higher risk of NIHL in the XPO5 gene rs7755135 CC carriers than in the TT carriers.
No statistically significant correlation was obtained with respect to SNPrs1106841.
Functional experiments showed that the rs11077 change might inhibit the interaction between miRNAs (miRNA-4763-5p, miRNA-5002-3p, and miRNA-617) and XPO5, with rs11077G allele resulting in overexpression of XPO5.
Conclusion.
The genetic polymorphism, rs11077, within XPO5 is associated with the risk of noise-induced hearing loss in a Chinese population.
American Psychological Association (APA)
Wang, Ning& Wang, Boshen& Guo, Jiadi& Zhang, Suhao& Han, Lei& Zhang, Juan…[et al.]. 2020. Single-Nucleotide Polymorphisms in XPO5 are Associated with Noise-Induced Hearing Loss in a Chinese Population. Biochemistry Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138481
Modern Language Association (MLA)
Wang, Ning…[et al.]. Single-Nucleotide Polymorphisms in XPO5 are Associated with Noise-Induced Hearing Loss in a Chinese Population. Biochemistry Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1138481
American Medical Association (AMA)
Wang, Ning& Wang, Boshen& Guo, Jiadi& Zhang, Suhao& Han, Lei& Zhang, Juan…[et al.]. Single-Nucleotide Polymorphisms in XPO5 are Associated with Noise-Induced Hearing Loss in a Chinese Population. Biochemistry Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138481
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138481