Efficacy of Thiamine in the Treatment of Postcardiac Arrest Patients: A Randomized Controlled Study
Joint Authors
Pradita-ukrit, Suntornwit
Vattanavanit, Veerapong
Source
Critical Care Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Thiamine administration has been shown to improve survival in a postcardiac arrest animal study.
We aimed to evaluate the efficacy of thiamine in comatose out-of-hospital cardiac arrest (OHCA) patients following return of spontaneous circulation.
Methods.
A randomized, double-blinded, placebo-controlled study was conducted.
Thirty-seven OHCA patients were randomly assigned to receive either thiamine 100 mg every 8 hours or a placebo.
The primary outcome was 28-day all-cause mortality.
Results.
Over the course of 2 years, 37 patients were randomized to either receive thiamine (n = 20) or a placebo (n = 17).
The primary outcome was not different between the groups: 10/20 (50%) in the thiamine group vs.
8/17 (47.1%) in the placebo group (P=0.93 by the log-rank test).
There were no significant differences in secondary outcomes between the groups (good neurological outcome, lactate level, and S100B level).
Conclusions.
In this study, there were no significant differences in survival outcome.
Further studies with a larger population are necessary to confirm these results.
American Psychological Association (APA)
Pradita-ukrit, Suntornwit& Vattanavanit, Veerapong. 2020. Efficacy of Thiamine in the Treatment of Postcardiac Arrest Patients: A Randomized Controlled Study. Critical Care Research and Practice،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1138506
Modern Language Association (MLA)
Pradita-ukrit, Suntornwit& Vattanavanit, Veerapong. Efficacy of Thiamine in the Treatment of Postcardiac Arrest Patients: A Randomized Controlled Study. Critical Care Research and Practice No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1138506
American Medical Association (AMA)
Pradita-ukrit, Suntornwit& Vattanavanit, Veerapong. Efficacy of Thiamine in the Treatment of Postcardiac Arrest Patients: A Randomized Controlled Study. Critical Care Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1138506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138506