Sodium-DNA for Bone Tissue Regeneration: An Experimental Study in Rat Calvaria
Joint Authors
Rodella, Luigi Fabrizio
Rezzani, Rita
Nocini, Pier Francesco
Borsani, Elisa
Albanese, Massimo
Sancassani, Guido
Labanca, Mauro
Favero, Gaia
Buffoli, Barbara
Boninsegna, Ramon
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Surgical techniques in dental and maxillofacial surgery request fast bone tissue regeneration, so there is a significant need to improve therapy for bone regeneration.
Several studies have recently underlined the importance of nucleotides and nucleosides to increase cell proliferation and activity; in particular, the ability of polydeoxyribonucleotide (PDRN) to induce growth and activity of human osteoblasts was demonstrated.
Sodium-DNA is the deoxyribonucleic acid (DNA) extracted from the gonadic tissue of male sturgeon and then purified, depolymerized, and neutralized with sodium hydroxide.
To date, there are no evidences about the use of Sodium-DNA for bone tissue regeneration.
Consequently, our question is about the efficacy of Sodium-DNA in bone healing.
For testing the role of Sodium-DNA in bone healing we used a rat calvarial defect model.
Sodium-DNA at different concentrations used alone or in association with Fibrin and/or Bio-Oss was used for healing treatments and the bone healing process was evaluated by histomorphometric and immunohistochemical analyses.
Our results suggested a positive effect of Sodium-DNA in bone regeneration, providing a useful protocol and a model for the future clinical evaluation of its osteogenic properties.
American Psychological Association (APA)
Buffoli, Barbara& Favero, Gaia& Borsani, Elisa& Boninsegna, Ramon& Sancassani, Guido& Labanca, Mauro…[et al.]. 2017. Sodium-DNA for Bone Tissue Regeneration: An Experimental Study in Rat Calvaria. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138513
Modern Language Association (MLA)
Buffoli, Barbara…[et al.]. Sodium-DNA for Bone Tissue Regeneration: An Experimental Study in Rat Calvaria. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1138513
American Medical Association (AMA)
Buffoli, Barbara& Favero, Gaia& Borsani, Elisa& Boninsegna, Ramon& Sancassani, Guido& Labanca, Mauro…[et al.]. Sodium-DNA for Bone Tissue Regeneration: An Experimental Study in Rat Calvaria. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138513
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138513