![](/images/graphics-bg.png)
Comparative Analysis and Classification of Cassette Exons and Constitutive Exons
Joint Authors
Stanley, H. E.
Cui, Ying
Cai, Meng
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Alternative splicing (AS) is a major engine that drives proteome diversity in mammalian genomes and is a widespread cause of human hereditary diseases.
More than 95% of genes in the human genome are alternatively spliced, and the most common type of AS is the cassette exon.
Recent discoveries have demonstrated that the cassette exon plays an important role in genetic diseases.
To discover the formation mechanism of cassette exon events, we statistically analyze cassette exons and find that cassette exon events are strongly influenced by individual exons that are smaller in size and that have a lower GC content, more codon terminations, and weaker splice sites.
We propose an improved random-forest-based hybrid method of distinguishing cassette exons from constitutive exons.
Our method achieves a high accuracy in classifying cassette exons and constitutive exons and is verified to outperform previous approaches.
It is anticipated that this study will facilitate a better understanding of the underlying mechanisms in cassette exons.
American Psychological Association (APA)
Cui, Ying& Cai, Meng& Stanley, H. E.. 2017. Comparative Analysis and Classification of Cassette Exons and Constitutive Exons. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138516
Modern Language Association (MLA)
Cui, Ying…[et al.]. Comparative Analysis and Classification of Cassette Exons and Constitutive Exons. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1138516
American Medical Association (AMA)
Cui, Ying& Cai, Meng& Stanley, H. E.. Comparative Analysis and Classification of Cassette Exons and Constitutive Exons. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138516