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Colorectal Cancer: From the Genetic Model to Posttranscriptional Regulation by Noncoding RNAs
Joint Authors
Lizarbe, María Antonia
Calle-Espinosa, Jorge
Fernández-Lizarbe, Eva
Fernández-Lizarbe, Sara
Robles, Miguel Ángel
Olmo, Nieves
Turnay, Javier
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-38, 38 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-10
Country of Publication
Egypt
No. of Pages
38
Main Subjects
Abstract EN
Colorectal cancer is the third most common form of cancer in developed countries and, despite the improvements achieved in its treatment options, remains as one of the main causes of cancer-related death.
In this review, we first focus on colorectal carcinogenesis and on the genetic and epigenetic alterations involved.
In addition, noncoding RNAs have been shown to be important regulators of gene expression.
We present a general overview of what is known about these molecules and their role and dysregulation in cancer, with a special focus on the biogenesis, characteristics, and function of microRNAs.
These molecules are important regulators of carcinogenesis, progression, invasion, angiogenesis, and metastases in cancer, including colorectal cancer.
For this reason, miRNAs can be used as potential biomarkers for diagnosis, prognosis, and efficacy of chemotherapeutic treatments, or even as therapeutic agents, or as targets by themselves.
Thus, this review highlights the importance of miRNAs in the development, progression, diagnosis, and therapy of colorectal cancer and summarizes current therapeutic approaches for the treatment of colorectal cancer.
American Psychological Association (APA)
Lizarbe, María Antonia& Calle-Espinosa, Jorge& Fernández-Lizarbe, Eva& Fernández-Lizarbe, Sara& Robles, Miguel Ángel& Olmo, Nieves…[et al.]. 2017. Colorectal Cancer: From the Genetic Model to Posttranscriptional Regulation by Noncoding RNAs. BioMed Research International،Vol. 2017, no. 2017, pp.1-38.
https://search.emarefa.net/detail/BIM-1138529
Modern Language Association (MLA)
Lizarbe, María Antonia…[et al.]. Colorectal Cancer: From the Genetic Model to Posttranscriptional Regulation by Noncoding RNAs. BioMed Research International No. 2017 (2017), pp.1-38.
https://search.emarefa.net/detail/BIM-1138529
American Medical Association (AMA)
Lizarbe, María Antonia& Calle-Espinosa, Jorge& Fernández-Lizarbe, Eva& Fernández-Lizarbe, Sara& Robles, Miguel Ángel& Olmo, Nieves…[et al.]. Colorectal Cancer: From the Genetic Model to Posttranscriptional Regulation by Noncoding RNAs. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-38.
https://search.emarefa.net/detail/BIM-1138529
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138529