Is Mitochondrial Oxidative Stress the Key Contributor to Diaphragm Atrophy and Dysfunction in Critically Ill Patients?
Joint Authors
Source
Critical Care Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diaphragm dysfunction is prevalent in the progress of respiratory dysfunction in various critical illnesses.
Respiratory muscle weakness may result in insufficient ventilation, coughing reflection suppression, pulmonary infection, and difficulty in weaning off respirators.
All of these further induce respiratory dysfunction and even threaten the patients’ survival.
The potential mechanisms of diaphragm atrophy and dysfunction include impairment of myofiber protein anabolism, enhancement of myofiber protein degradation, release of inflammatory mediators, imbalance of metabolic hormones, myonuclear apoptosis, autophagy, and oxidative stress.
Among these contributors, mitochondrial oxidative stress is strongly implicated to play a key role in the process as it modulates diaphragm protein synthesis and degradation, induces protein oxidation and functional alteration, enhances apoptosis and autophagy, reduces mitochondrial energy supply, and is regulated by inflammatory cytokines via related signaling molecules.
This review aims to provide a concise overview of pathological mechanisms of diaphragmatic dysfunction in critically ill patients, with special emphasis on the role and modulating mechanisms of mitochondrial oxidative stress.
American Psychological Association (APA)
Duan, Hongjie& Bai, Hailiang. 2020. Is Mitochondrial Oxidative Stress the Key Contributor to Diaphragm Atrophy and Dysfunction in Critically Ill Patients?. Critical Care Research and Practice،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138541
Modern Language Association (MLA)
Duan, Hongjie& Bai, Hailiang. Is Mitochondrial Oxidative Stress the Key Contributor to Diaphragm Atrophy and Dysfunction in Critically Ill Patients?. Critical Care Research and Practice No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1138541
American Medical Association (AMA)
Duan, Hongjie& Bai, Hailiang. Is Mitochondrial Oxidative Stress the Key Contributor to Diaphragm Atrophy and Dysfunction in Critically Ill Patients?. Critical Care Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138541
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138541