Vitamin B-6, Independent of Homocysteine, Is a Significant Factor in Relation to Inflammatory Responses for Chronic Kidney Disease and Hemodialysis Patients
Joint Authors
Huang, Yi-Chia
Huang, Shih-Chien
Yeh, En-Ling
Chen, Chih-Chung
Chen, Cheng-Hsu
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The purpose of this study was to investigate whether plasma pyridoxal 5′-phosphate (PLP) and homocysteine were dependent on or independent of each other in order to be associated with inflammatory markers in patients with chronic kidney disease (CKD) or those receiving hemodialysis treatment.
This was a cross-sectional study.
Sixty-eight stage 2–5 CKD patients and 68 hemodialysis patients had one time fasting blood drawn for measurements of plasma PLP, pyridoxal (PL), homocysteine, and several inflammatory markers.
Early CKD stage (stages 2-3) patients showed significantly lower plasma PLP levels and homocysteine concentrations than patients in an advanced CKD stage (stages 4-5) and those undergoing hemodialysis.
Plasma PLP significantly correlated with CRP levels (partial rs = −0.21, p<0.05) and plasma PL significantly correlated with IL-10 levels (partial rs = −0.24, p<0.01), while plasma PLP plus PL significantly correlated with both CRP levels (partial rs = −0.20, p<0.05) and interleukin-1β (partial rs = 0.22, p<0.05) levels after adjusting for plasma homocysteine and other potential confounders.
Plasma homocysteine displayed no significant correlations with any inflammatory markers.
Vitamin B-6 status, rather than homocysteine, appeared to be a significant factor in relation to inflammatory responses for CKD and hemodialysis patients.
American Psychological Association (APA)
Chen, Cheng-Hsu& Yeh, En-Ling& Chen, Chih-Chung& Huang, Shih-Chien& Huang, Yi-Chia. 2017. Vitamin B-6, Independent of Homocysteine, Is a Significant Factor in Relation to Inflammatory Responses for Chronic Kidney Disease and Hemodialysis Patients. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138544
Modern Language Association (MLA)
Chen, Cheng-Hsu…[et al.]. Vitamin B-6, Independent of Homocysteine, Is a Significant Factor in Relation to Inflammatory Responses for Chronic Kidney Disease and Hemodialysis Patients. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1138544
American Medical Association (AMA)
Chen, Cheng-Hsu& Yeh, En-Ling& Chen, Chih-Chung& Huang, Shih-Chien& Huang, Yi-Chia. Vitamin B-6, Independent of Homocysteine, Is a Significant Factor in Relation to Inflammatory Responses for Chronic Kidney Disease and Hemodialysis Patients. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138544
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138544