Inhibitory Effect of Chemical Constituents Isolated from Artemisia iwayomogi on Polyol Pathway and Simultaneous Quantification of Major Bioactive Compounds
Joint Authors
Lee, Yoon Kyoung
Hong, Eun Young
Whang, Wan Kyunn
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Blocking the polyol pathway plays an important role preventing diabetic complications.
Therefore, aldose reductase (AR) and advanced glycation endproducts (AGEs) formation has significant effect on diabetic complications.
Artemisia iwayomogi has long been used as treatment of various diseases in Korea.
However, no literatures have reported on AR and AGEs formation inhibitory activities of A.
iwayomogi.
For these reasons, we aimed to assess that A.
iwayomogi had potential as anti-diabetic complications agents.
We led to isolation of two coumarins (1 and 2), nine flavonoids (3–11), five caffeoylquinic acids (12–16), three diterpene glycosides (17–19), and one phenolic compound (20) from A.
iwayomogi.
Among them, hispidulin (4), 6-methoxytricin (6), arteanoflavone (7), quercetin-3-gentiobioside (10), 1,3-di-O-caffeoylquinic acid (13), and suavioside A (18) were first reported on the isolation from A.
iwayomogi.
Not only two coumarins (1 and 2), nine flavonoids (3–11), and five caffeoylquinic acids (12–16) but also extracts showed significant inhibitor on AR and AGEs formation activities.
We analyzed contents of major bioactive compounds in Korea’s various regions of A.
iwayomogi.
Overall, we selected Yangyang, Gangwon-do, from June, which contained the highest amounts of bioactive compounds, as suitable areas for cultivating A.
iwayomogi as preventive or therapeutic agent in the treatment of diabetic complications.
American Psychological Association (APA)
Lee, Yoon Kyoung& Hong, Eun Young& Whang, Wan Kyunn. 2017. Inhibitory Effect of Chemical Constituents Isolated from Artemisia iwayomogi on Polyol Pathway and Simultaneous Quantification of Major Bioactive Compounds. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138547
Modern Language Association (MLA)
Lee, Yoon Kyoung…[et al.]. Inhibitory Effect of Chemical Constituents Isolated from Artemisia iwayomogi on Polyol Pathway and Simultaneous Quantification of Major Bioactive Compounds. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1138547
American Medical Association (AMA)
Lee, Yoon Kyoung& Hong, Eun Young& Whang, Wan Kyunn. Inhibitory Effect of Chemical Constituents Isolated from Artemisia iwayomogi on Polyol Pathway and Simultaneous Quantification of Major Bioactive Compounds. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138547
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138547