miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14
Joint Authors
Wang, Tong
Ren, Yipeng
Liu, Ruixun
Ma, Juntao
Shi, Yueyi
Zhang, Lei
Bu, Rongfa
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-24
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
MicroRNAs (miRNAs) play an essential role in tumor biological processes through interacting with specific gene targets.
The involvement of miR-195-5p in cell proliferation, invasion, and migration has been demonstrated in several cancer cell lines, while its function in oral squamous cell carcinoma (OSCC) remains unclear.
Here we find that miR-195-5p expression is lower in OSCC than in nontumor tissues, while its overexpression in cell lines can lead to the promotion of apoptosis and the reduction of cell growth, migration, and invasion.
Moreover, we identify the tripartite motif-containing protein (TRIM14) as a target of miR-195-5p.
Therefore, we reason that the tumor suppressor role of miR-195-5p in OSCC is dependent on the interaction with TRIM14.
American Psychological Association (APA)
Wang, Tong& Ren, Yipeng& Liu, Ruixun& Ma, Juntao& Shi, Yueyi& Zhang, Lei…[et al.]. 2017. miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1138552
Modern Language Association (MLA)
Wang, Tong…[et al.]. miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1138552
American Medical Association (AMA)
Wang, Tong& Ren, Yipeng& Liu, Ruixun& Ma, Juntao& Shi, Yueyi& Zhang, Lei…[et al.]. miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1138552
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138552