GosB Inhibits Triacylglycerol Synthesis and Promotes Cell Survival in Mouse Mammary Epithelial Cells
Joint Authors
Xu, Gaoxiao
Duan, Saixing
Hou, Jianye
Wei, Zhongxin
Zhao, Guangwei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
It has been demonstrated that the activator protein related transcription factor Finkel-Biskis-Jinkins murine osteosarcoma B (GosB) is involved in preadipocyte differentiation and triacylglycerol synthesis.
However, the role of GosB in regulating the synthesis of milk fatty acid in mouse mammary glands remains unclear.
This research uncovered potentially new roles of GosB in suppressing milk fatty acid synthesis.
Results revealed that GosB had the highest expression in lung tissue and showed a higher expression level during nonlactation than during lactation.
GosB inhibited the expression of fatty acid synthase (FASN), stearoyl-CoA desaturase (SCD), fatty acid binding protein 4 (FABP4), diacylglycerol acyltransferase 1 (DGAT1), perilipin 2 (PLIN2), perilipin 3 (PLIN3), and C/EBPα in mouse mammary gland epithelial cells (MEC).
In addition, GosB reduced cellular triglyceride content and the accumulation of lipid droplets; in particular, GosB enhanced saturated fatty acid concentration (C16:0 and C18:0).
The PPARγ agonist, rosiglitazone (ROSI), promoted apoptosis and inhibited cell proliferation.
GosB increased the expression of Bcl-2 and protected MEC from ROSI-induced apoptosis.
Furthermore, MECs were protected from apoptosis through the GosB regulation of intracellular calcium concentrations.
These findings suggest that GosB may regulate mammary epithelial cells milk fat synthesis and apoptosis via PPARγ in mouse mammary glands.
American Psychological Association (APA)
Xu, Gaoxiao& Duan, Saixing& Hou, Jianye& Wei, Zhongxin& Zhao, Guangwei. 2017. GosB Inhibits Triacylglycerol Synthesis and Promotes Cell Survival in Mouse Mammary Epithelial Cells. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138556
Modern Language Association (MLA)
Xu, Gaoxiao…[et al.]. GosB Inhibits Triacylglycerol Synthesis and Promotes Cell Survival in Mouse Mammary Epithelial Cells. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1138556
American Medical Association (AMA)
Xu, Gaoxiao& Duan, Saixing& Hou, Jianye& Wei, Zhongxin& Zhao, Guangwei. GosB Inhibits Triacylglycerol Synthesis and Promotes Cell Survival in Mouse Mammary Epithelial Cells. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138556
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138556