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Recombinant Human Brain Natriuretic Peptide Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting CD4+ T Cell Proliferation via PI3KAKTmTOR Pathway Activation
Joint Authors
Li, Kun-Peng
Zhang, Hai-Yan
Xu, Xiao-Dong
Ming-Yang, Xiao-Dong
Li, Tie-Jun
Song, Shu-Tian
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Inflammation plays a major role in the development of myocardial ischemia-reperfusion (IR) injury.
Recombinant human brain natriuretic peptide (rhBNP), a man-made version of a peptide that is elevated in heart failure, exhibits anti-inflammatory effects in various tissues.
However, its role in myocardial IR injury remains unclear.
In this study, we demonstrate that treatment with rhBNP provided protection for mice against myocardial IR injury as manifested by reduced infarct size and well-preserved myocardial, attenuated inflammatory infiltration and CD4+ T cell proliferation function, and inhibited expression of proinflammatory related genes.
Furthermore, mechanistic studies revealed that rhBNP inhibited Jurkat T proliferation by promoting PI3K/AKT/mTOR phosphorylation.
Collectively, our data suggest that the administration of rhBNP during IR injury could expand our understanding of the cardioprotective effects of rhBNP.
American Psychological Association (APA)
Li, Kun-Peng& Zhang, Hai-Yan& Xu, Xiao-Dong& Ming-Yang, Xiao-Dong& Li, Tie-Jun& Song, Shu-Tian. 2020. Recombinant Human Brain Natriuretic Peptide Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting CD4+ T Cell Proliferation via PI3KAKTmTOR Pathway Activation. Cardiovascular Therapeutics،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138566
Modern Language Association (MLA)
Li, Kun-Peng…[et al.]. Recombinant Human Brain Natriuretic Peptide Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting CD4+ T Cell Proliferation via PI3KAKTmTOR Pathway Activation. Cardiovascular Therapeutics No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1138566
American Medical Association (AMA)
Li, Kun-Peng& Zhang, Hai-Yan& Xu, Xiao-Dong& Ming-Yang, Xiao-Dong& Li, Tie-Jun& Song, Shu-Tian. Recombinant Human Brain Natriuretic Peptide Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting CD4+ T Cell Proliferation via PI3KAKTmTOR Pathway Activation. Cardiovascular Therapeutics. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138566
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138566