Estrogen Replacement Regulates Vaginal Innervations in Ovariectomized Adult Virgin Rats: A Histological Study
Joint Authors
Li, Ting
Li, Ting
Ma, Yuanyuan
Yan, Ping
Huo, Lili
Hu, Yongyan
Chen, Xi
Zhang, Miao
Zhang, Hong
Liu, Zhaohui
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Our previous Gräfenberg spot findings confirmed that the distal-third areas of the anterior vaginal wall bore a significantly greater number of nerves and sexual hormone may have certain degree of influence on these significant differences.
However, the role of estrogen in vaginal innervations remains controversial.
Methods.
To investigate whether hormonal-neural interactions occur in the vagina, sixty rats were randomly divided into six groups: Sham-operated, ovariectomy, and 4 treatment groups.
After 2 weeks of treatment, vaginal biopsies were prepared with hematoxylin and eosin and PGP9.5 using immunohistochemistry.
Results.
The density of small nerve fibers was significantly higher in the distal-half areas of intact vaginal walls than the proximal-half areas (P=0.001).
In contrast, the overall PGP 9.5-ir fiber innervation density was significantly decreased in the OVX rats subjected to surgical menopause.
Sustained estrogen administration for 2 weeks resulted in nerve fiber proliferation, with values reaching normal levels in the low-dose estradiol valerate group.
Conclusion.
Our findings indicate that systemic hormonal therapy with low-dose estradiol valerate is effective and safe for treating deficient vaginal innervation caused by low level of estrogen activity in menopausal women and may aid studies to identify an optimal estradiol dose to provide relief from vaginal discomfort.
American Psychological Association (APA)
Zhang, Hong& Yan, Ping& Huo, Lili& Hu, Yongyan& Chen, Xi& Li, Ting…[et al.]. 2017. Estrogen Replacement Regulates Vaginal Innervations in Ovariectomized Adult Virgin Rats: A Histological Study. BioMed Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1138591
Modern Language Association (MLA)
Zhang, Hong…[et al.]. Estrogen Replacement Regulates Vaginal Innervations in Ovariectomized Adult Virgin Rats: A Histological Study. BioMed Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1138591
American Medical Association (AMA)
Zhang, Hong& Yan, Ping& Huo, Lili& Hu, Yongyan& Chen, Xi& Li, Ting…[et al.]. Estrogen Replacement Regulates Vaginal Innervations in Ovariectomized Adult Virgin Rats: A Histological Study. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1138591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138591