Left Ventricular Ejection Fraction Is Associated with the Risk of Thrombus in the Left Atrial Appendage in Patients with Atrial Fibrillation
Joint Authors
Krzesiński, Paweł
Gielerak, Grzegorz
Uziębło-Życzkowska, Beata
Jurek, Agnieszka
Kapłon-Cieślicka, Agnieszka
Gorczyca, Iwona
Budnik, Monika
Kiliszek, Marek
Gawałko, Monika
Scisło, Piotr
Kochanowski, Janusz
Jelonek, Olga
Michalska, Anna
Starzyk, Katarzyna
Filipiak, Krzysztof J.
Wożakowska-Kapłon, Beata
Opolski, Grzegorz
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Atrial fibrillation (AF) is associated with high risk of ischemic stroke.
The most frequent thrombus location in AF is the left atrial appendage (LAA).
Transthoracic echocardiography (TTE) is a basic diagnostic examination in patients (pts) with AF.
Objectives.
To analyse the relations between basic echocardiographic features, well-established stroke risk factors, type of AF, and anticoagulation therapy with the incidence of left atrial appendage thrombus (LAAT).
Patients and Methods.
The study group consisted of 768 pts with AF (mean age, 63 years), admitted to three high-reference cardiology departments.
Five hundred and twenty-three pts were treated with non-vitamin K antagonist oral anticoagulants (NOACs) and 227 (30%) with vitamin K antagonists (VKAs).
The subjects underwent TTE and transesophageal echocardiography (TEE) before cardioversion or ablation.
Results.
LAAT was significantly more frequent in pts with reduced left ventricular ejection fraction (LVEF): in 10.6% (7 pts) with LVEF<40% and in 9.0% (9 pts) with LVEF 40-49%, while only in 5.5% (33 pts) with LVEF>50%.
Compared to pts without LAAT, those with LAAT presented with lower LVEF and higher left atrial diameter (LAD).
Multivariate logistic regression revealed the following variables as independent predictors of LAAT: previous bleeding, treatment with VKA, and LVEF.
Conclusion.
LAAT is related to lower LVEF and higher LAD.
LVEF is one of the independent predictors of LAAT.
Even in the case of adequate anticoagulant therapy, it might be prudent to consider TEE before cardioversion or ablation in patients with low LVEF and LA enlargement, especially in the coexistence of other thromboembolic risk factors.
American Psychological Association (APA)
Uziębło-Życzkowska, Beata& Krzesiński, Paweł& Jurek, Agnieszka& Kapłon-Cieślicka, Agnieszka& Gorczyca, Iwona& Budnik, Monika…[et al.]. 2020. Left Ventricular Ejection Fraction Is Associated with the Risk of Thrombus in the Left Atrial Appendage in Patients with Atrial Fibrillation. Cardiovascular Therapeutics،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1138592
Modern Language Association (MLA)
Uziębło-Życzkowska, Beata…[et al.]. Left Ventricular Ejection Fraction Is Associated with the Risk of Thrombus in the Left Atrial Appendage in Patients with Atrial Fibrillation. Cardiovascular Therapeutics No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1138592
American Medical Association (AMA)
Uziębło-Życzkowska, Beata& Krzesiński, Paweł& Jurek, Agnieszka& Kapłon-Cieślicka, Agnieszka& Gorczyca, Iwona& Budnik, Monika…[et al.]. Left Ventricular Ejection Fraction Is Associated with the Risk of Thrombus in the Left Atrial Appendage in Patients with Atrial Fibrillation. Cardiovascular Therapeutics. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1138592
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138592