Association between P2RY12 Gene Polymorphisms and IVIG Resistance in Kawasaki Patients
Joint Authors
Wang, Yanfei
Wang, Zhouping
Xu, Yufen
Zhou, Huazhong
Li, Wei
Lu, Zhaoliang
Jiang, Zhiyong
Gu, Xueping
Zheng, Hao
Zeng, Lanlan
Huang, Ping
Zhang, Li
Gu, Xiaoqiong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Children with Kawasaki disease (KD) resistant to intravenous immunoglobulin (IVIG) have a higher incidence of coronary artery lesions (CAL).
Despite the association between Purinergic receptor P2Y12 (P2RY12) polymorphism, KD genetic susceptibility, and CAL complications being proved, few studies have assessed the relationship between P2RY12 polymorphisms and IVIG resistance in patients with KD.
We recruited 148 KD patients with IVIG resistance and 611 with IVIG sensitivity and selected five P2RY12 polymorphisms: rs9859538, rs1491974, rs7637803, rs6809699, and rs2046934.
A significant difference in the genotype distributions between patients was only observed for the rs6809699 A > C polymorphism (AC vs.
AA: adjusted odds ratio (OR) = 0.48, 95% confidence interval (CI) = 0.27–0.84, P=0.011; AC/CC vs.
AA: adjusted OR = 0.47, 95% CI = 0.27–0.83, P=0.0084).
After adjusting for age and gender, the carriers of the rs6809699 C allele had OR of 0.44 to 0.49 for IVIG sensitivity (AC vs.
AA: adjusted OR = 0.48, 95% confidence interval (CI) = 0.27–0.84, P=0.011; AC/CC vs.
AA: adjusted OR = 0.47, 95% CI = 0.27–0.83, P=0.0084) compared to the carriers of a rs6809699 AA genotype, suggesting the protective effect of this SNP against IVIG resistance.
Moreover, individuals with all five protective polymorphisms experienced a significantly decreased IVIG resistance compared to that of individuals with up to three protective polymorphisms (adjusted OR = 0.27, 95% CI = 0.13–0.57, P=0.0006).
Our results suggest that the P2RY12 rs6809699 polymorphism could be used as a biomarker to predict IVIG resistance in KD patients.
American Psychological Association (APA)
Wang, Zhouping& Xu, Yufen& Zhou, Huazhong& Wang, Yanfei& Li, Wei& Lu, Zhaoliang…[et al.]. 2020. Association between P2RY12 Gene Polymorphisms and IVIG Resistance in Kawasaki Patients. Cardiovascular Therapeutics،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1138593
Modern Language Association (MLA)
Wang, Zhouping…[et al.]. Association between P2RY12 Gene Polymorphisms and IVIG Resistance in Kawasaki Patients. Cardiovascular Therapeutics No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1138593
American Medical Association (AMA)
Wang, Zhouping& Xu, Yufen& Zhou, Huazhong& Wang, Yanfei& Li, Wei& Lu, Zhaoliang…[et al.]. Association between P2RY12 Gene Polymorphisms and IVIG Resistance in Kawasaki Patients. Cardiovascular Therapeutics. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1138593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138593