Low Ethanol Concentrations Promote Endothelial Progenitor Cell Capacity and Reparative Function
Joint Authors
Brodowski, Lars
Schröder-Heurich, Bianca
Kipke, Berina
Schmidt, Cara
von Kaisenberg, Constantin S.
von Versen-Höynck, Frauke
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Endothelial progenitor cells (EPCs) are recruited to injured endothelium and contribute to its regeneration.
There is evidence that moderate ethanol consumption prevents the development and progression of atherosclerosis in a variety of in vitro and in vivo models and increases the mobilization of progenitor cells.
Furthermore, there are studies that identified ethanol at low concentration as a therapeutic tool to mobilize progenitor cells in peripheral blood.
At the same time, the cell number of EPCs represents a close link to cardiovascular system constitution and function and contributes to cardiovascular risk.
The aim of this study was to evaluate the effect of low dose ethanol on typical features of endothelial colony-forming cells (ECFCs), a proliferative subtype of EPCs.
Methods and Results.
We tested whether ethanol impacts the functional abilities of ECFC (e.g., migration, tube formation, and proliferation) using in vitro assays, the intercommunication of ECFC by exploring cell surface molecules by flow cytometry, and the expression of (anti-)angiogenic molecules by ELISA.
Low concentrations of ethanol concentration promoted migration, proliferation, and tubule formation of ECFC.
The expression of the cell surface marker VE-cadherin, a protein which plays an important role in cell-cell interaction, was enhanced by ethanol, while (anti-)angiogenic molecule expression was not impacted.
Conclusion.
Ethanol at moderate concentrations increases the angiogenic abilities of endothelial progenitor cells thus possibly contributing to vasoprotection.
American Psychological Association (APA)
Brodowski, Lars& Schröder-Heurich, Bianca& Kipke, Berina& Schmidt, Cara& von Kaisenberg, Constantin S.& von Versen-Höynck, Frauke. 2020. Low Ethanol Concentrations Promote Endothelial Progenitor Cell Capacity and Reparative Function. Cardiovascular Therapeutics،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138599
Modern Language Association (MLA)
Brodowski, Lars…[et al.]. Low Ethanol Concentrations Promote Endothelial Progenitor Cell Capacity and Reparative Function. Cardiovascular Therapeutics No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1138599
American Medical Association (AMA)
Brodowski, Lars& Schröder-Heurich, Bianca& Kipke, Berina& Schmidt, Cara& von Kaisenberg, Constantin S.& von Versen-Höynck, Frauke. Low Ethanol Concentrations Promote Endothelial Progenitor Cell Capacity and Reparative Function. Cardiovascular Therapeutics. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138599
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138599