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Association of β-Blocker Therapy at Discharge with Clinical Outcomes after Acute Coronary Syndrome in Patients without Heart Failure
Joint Authors
Xu, Bo
Chen, Yan
Tang, Xiao-fang
Gao, Run-lin
Yang, Yue-jin
Yuan, Jin-qing
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aim.
To evaluate the clinical impact of β-blocker in patients with adequate left ventricular ejection function (LVEF) who underwent percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS).
Methods.
A total of 10,724 consecutive patients who underwent PCI throughout 2013 were prospectively enrolled in the study.
Among these, we analyzed 5,631 ACS patients who were discharged with LVEF≥40%.
Patients were then compared according to the β-blocker prescription at discharge.
Results.
During a 2-year follow-up, no significant association was observed of β-blocker use with all-cause mortality (with β-blockers 47/5,043 (0.9%) vs.
without β-blocker use 8/588 (1.4%); hazard ratio (HR) 0.762, 95% confidence interval 0.36 to 1.64; P=0.485), cardiac death, myocardial infarction (MI), or major adverse cardiovascular and cerebrovascular events.
Subgroup analysis demonstrated that the β-blocker use at discharge reduced the 2-year mortality in patients with unstable angina (UA) (HR 0.42, 95% CI 0.19 to 0.94, P=0.034).
Landmark analysis at 1 year showed that patients with UA who were discharged with β-blockers had lower mortality (HR 0.17, 95% CI 0.04-0.65, P=0.010) and cardiac death (HR 0.12, 95% CI 0.01-0.99, P=0.049) than those discharged without β-blockers.
However, the benefit was lost beyond 1 year.
No differences in outcomes were recorded in the AMI or overall population.
Conclusions.
We present that β-blocker significantly lowers the rate of all-cause death up to 1 year, in UA patients who have undergone PCI and have adequate LVEF.
Its role in patients with AMI also deserves further exploration.
American Psychological Association (APA)
Chen, Yan& Tang, Xiao-fang& Gao, Run-lin& Yang, Yue-jin& Xu, Bo& Yuan, Jin-qing. 2020. Association of β-Blocker Therapy at Discharge with Clinical Outcomes after Acute Coronary Syndrome in Patients without Heart Failure. Cardiovascular Therapeutics،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138603
Modern Language Association (MLA)
Chen, Yan…[et al.]. Association of β-Blocker Therapy at Discharge with Clinical Outcomes after Acute Coronary Syndrome in Patients without Heart Failure. Cardiovascular Therapeutics No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1138603
American Medical Association (AMA)
Chen, Yan& Tang, Xiao-fang& Gao, Run-lin& Yang, Yue-jin& Xu, Bo& Yuan, Jin-qing. Association of β-Blocker Therapy at Discharge with Clinical Outcomes after Acute Coronary Syndrome in Patients without Heart Failure. Cardiovascular Therapeutics. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138603