Calcifying Matrix Vesicles and Atherosclerosis
Joint Authors
Myasoedova, Veronika A.
Chistiakov, Dimitry A.
Grechko, Andrey V.
Orekhov, Alexander N.
Melnichenko, Alexandra A.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Artery calcification is a well-recognized predictor of late atherosclerotic complications.
In the intima media, calcification starts with apoptosis of vascular smooth muscle cells (VSMCs) and the release of calcifying matrix vesicles with diameter of 0.5–15 μm that can be observed microscopically.
In complicated plaques, calcification is generally less frequent.
Calcifying vesicles are released by proatherosclerotic VSMCs into the collagen-rich matrix.
The vesicles can penetrate into the intima media and protrude into the arterial lumen and thereby may represent a potential cause of atherothrombosis.
In calcified fibrolipid plaques, the rate of calcification is increased but is followed with healing of a lesion rupture and exhibited by further erosion and/or intimal thickening.
Generally, calcification directly correlates with the apoptosis of VSMCs and macrophages accompanied by the release of osteogenic matrix vesicles.
This is a hallmark of atherosclerosis-related apoptosis of VSMCs that is commonly released in plaque stabilization.
American Psychological Association (APA)
Chistiakov, Dimitry A.& Myasoedova, Veronika A.& Melnichenko, Alexandra A.& Grechko, Andrey V.& Orekhov, Alexander N.. 2017. Calcifying Matrix Vesicles and Atherosclerosis. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138605
Modern Language Association (MLA)
Chistiakov, Dimitry A.…[et al.]. Calcifying Matrix Vesicles and Atherosclerosis. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1138605
American Medical Association (AMA)
Chistiakov, Dimitry A.& Myasoedova, Veronika A.& Melnichenko, Alexandra A.& Grechko, Andrey V.& Orekhov, Alexander N.. Calcifying Matrix Vesicles and Atherosclerosis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138605