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Association between Serum Vitamin C and the Blood Pressure: A Systematic Review and Meta-Analysis of Observational Studies
Joint Authors
Bu, Huaien
Zhao, Ye
Zhao, Wenli
Ran, Li
Tan, Xiaodong
Mizuno, Kaito
Takagi, Ken
Wang, Hongwu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Hypertension is regarded as a major and independent risk factor of cardiovascular diseases, and numerous studies observed an inverse correlation between vitamin C intake and blood pressure.
Aim.
Our aim is to investigate the relationship between serum vitamin C and blood pressure, including the concentration differences and the correlation strength.
Method.
Two independent researchers searched and screened articles from the National Library of Medicine, Cochrane Library, Web of Science, China National Knowledge Infrastructure, VIP databases, and WANFANG databases.
A total of 18 eligible studies were analyzed in the Reviewer Manager 5.3 software, including 14 English articles and 4 Chinese articles.
Results.
In the evaluation of serum vitamin C levels, the concentration in hypertensive subjects is 15.13 μmol/L lower than the normotensive ones (mean difference=−15.13, 95% CI [-24.19, -6.06], and P=0.001).
Serum vitamin C has a significant inverse relation with both systolic blood pressure (Fisher’s Z=−0.17, 95% CI [-0.20, -0.15], P<0.00001) and diastolic blood pressure (Fisher’s Z=−0.15, 95% CI [-0.20, -0.10], P<0.00001).
Conclusions.
People with hypertension have a relatively low serum vitamin C, and vitamin C is inversely associated with both systolic blood pressure and diastolic blood pressure.
American Psychological Association (APA)
Ran, Li& Zhao, Wenli& Tan, Xiaodong& Wang, Hongwu& Mizuno, Kaito& Takagi, Ken…[et al.]. 2020. Association between Serum Vitamin C and the Blood Pressure: A Systematic Review and Meta-Analysis of Observational Studies. Cardiovascular Therapeutics،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1138607
Modern Language Association (MLA)
Ran, Li…[et al.]. Association between Serum Vitamin C and the Blood Pressure: A Systematic Review and Meta-Analysis of Observational Studies. Cardiovascular Therapeutics No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1138607
American Medical Association (AMA)
Ran, Li& Zhao, Wenli& Tan, Xiaodong& Wang, Hongwu& Mizuno, Kaito& Takagi, Ken…[et al.]. Association between Serum Vitamin C and the Blood Pressure: A Systematic Review and Meta-Analysis of Observational Studies. Cardiovascular Therapeutics. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1138607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138607