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Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ1–42-Induced Rat Model of Alzheimer’s Disease
Joint Authors
Wang, Zhe
Sheng, Chenxia
Xu, Panpan
Zhou, Kexin
Deng, Dan
Zhang, Chunhu
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Icariin (ICA), a prenylated flavanol glycoside present in abundant quantities in Epimedium sagittatum, has shown promise in the treatment and prevention of Alzheimer’s disease.
Damage to synaptic plasticity induced by amyloid-beta-mediated neurotoxicity is considered a main pathological mechanism driving the learning and memory deficits present in patients with Alzheimer’s disease.
This study investigated the neuroprotective effects of icariin in an Aβ1–42-induced rat model of Alzheimer’s disease.
Our results showed that Aβ1–42 injection induced loss of learning and memory behaviour in the Morris water maze, which could be reversed with intragastric administration of ICA.
Furthermore, ICA reversed decreases in PSD-95, BDNF, pTrkB, pAkt, and pCREB expressions and prevented deterioration of synaptic interface structure.
These findings indicate that ICA may improve synaptic plasticity through the BDNF/TrkB/Akt pathway and provide further evidence for its clinical application to improve learning and memory in patients with Alzheimer’s disease.
American Psychological Association (APA)
Sheng, Chenxia& Xu, Panpan& Zhou, Kexin& Deng, Dan& Zhang, Chunhu& Wang, Zhe. 2017. Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ1–42-Induced Rat Model of Alzheimer’s Disease. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138608
Modern Language Association (MLA)
Sheng, Chenxia…[et al.]. Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ1–42-Induced Rat Model of Alzheimer’s Disease. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1138608
American Medical Association (AMA)
Sheng, Chenxia& Xu, Panpan& Zhou, Kexin& Deng, Dan& Zhang, Chunhu& Wang, Zhe. Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ1–42-Induced Rat Model of Alzheimer’s Disease. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138608
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138608