Mixed Lactobacillus plantarum Strains Inhibit Staphylococcus aureus Induced Inflammation and Ameliorate Intestinal Microflora in Mice
Joint Authors
Zhu, Jianwei
Gong, Shengjie
Liu, Hongyan
Shu, Jingyan
Rong, Fengjun
Zhang, Zhenye
Wang, Di
Gao, Liangfeng
Qu, Tianming
Chen, Ping
Ren, Dayong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Staphylococcus aureus is an important pathogen that causes intestinal infection.
We examined the immunomodulatory function of single and mixed Lactobacillus plantarum strains, as well as their impacts on the structure of the microbiome in mice infected with Staphylococcus aureus.
The experiment was divided into three groups: protection, treatment, and control.
Serum IFN-γ and IL-4 levels, as well as intestinal sIgA levels, were measured during and 1 week after infection with Staphylococcus aureus with and without Lactobacillus plantarum treatment.
We used 16s rRNA tagged sequencing to analyze microbiome composition.
IFN-γ/IL-4 ratio decreased significantly from infection to convalescence, especially in the mixed Lactobacillus plantarum group.
In the mixed Lactobacillus plantarum group the secretion of sIgA in the intestine of mice (9.4–9.7 ug/mL) was significantly higher than in the single lactic acid bacteria group.
The dominant phyla in mice are Firmicutes, Bacteroidetes, and Proteobacteria.
Treatment with mixed lactic acid bacteria increased the anti-inflammatory factor and the secretion of sIgA in the intestine of mice infected with Staphylococcus aureus and inhibited inflammation.
American Psychological Association (APA)
Ren, Dayong& Gong, Shengjie& Shu, Jingyan& Zhu, Jianwei& Rong, Fengjun& Zhang, Zhenye…[et al.]. 2017. Mixed Lactobacillus plantarum Strains Inhibit Staphylococcus aureus Induced Inflammation and Ameliorate Intestinal Microflora in Mice. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138616
Modern Language Association (MLA)
Ren, Dayong…[et al.]. Mixed Lactobacillus plantarum Strains Inhibit Staphylococcus aureus Induced Inflammation and Ameliorate Intestinal Microflora in Mice. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1138616
American Medical Association (AMA)
Ren, Dayong& Gong, Shengjie& Shu, Jingyan& Zhu, Jianwei& Rong, Fengjun& Zhang, Zhenye…[et al.]. Mixed Lactobacillus plantarum Strains Inhibit Staphylococcus aureus Induced Inflammation and Ameliorate Intestinal Microflora in Mice. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138616
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138616