Effects of Angiotensin-Converting Enzyme Inhibitors on Arterial Stiffness: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Joint Authors
Wang, Qiongying
Bai, Feng
Li, Xiuli
Chang, Peng
Hu, Hao
Li, Ningyin
Yu, Jing
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
To determine the effects of ACEIs on arterial stiffness, a meta-analysis of randomized controlled trials was conducted.
Relevant articles that investigated the effects of ACEIs on arterial stiffness from PubMed, Embase, and the Cochrane library from inception to September 2018 were systematically retrieved.
The investigated outcomes included brachial-ankle pulse wave velocity (ba-PWV) and carotid-femoral PWV (cf-PWV) by using weighted mean differences (WMDs) and 95% confidence intervals (CIs) with the random-effects model.
A total of 17 RCTs including 1,458 individuals were included.
The summary results indicated no significant differences between ACEIs and control for ba-PWV and cf-PWV.
Also, no significant differences between ACEI and control for ba-PWV and cf-PWV were observed in hypertensive patients, while the therapeutic effects of ACEI versus placebo showed statistically significant difference.
Moreover, subgroup analysis indicated that the levels of ba-PWV were significantly associated if the study was conducted in Western countries, mean age <60.0 years, percentage male ≥60.0%, compared with ARBs, baseline PWV <10.0, and high-quality study.
Furthermore, the significant levels of cf-PWV in patients who received ACEIs were observed when percentage male was ≥60.0% and the studies were of high-quality.
Finally, no significant differences were observed between ACEIs and other antihypertensive drugs regarding the changes of systolic blood pressure (SBP) and diastolic blood pressure (DBP).
The overall analysis suggested no significant differences between ACEIs and other antihypertensive drugs for ba-PWV and cf-PWV levels, whereas ACEIs versus placebo showed lower levels of ba-PWV and cf-PWV.
American Psychological Association (APA)
Li, Xiuli& Chang, Peng& Wang, Qiongying& Hu, Hao& Bai, Feng& Li, Ningyin…[et al.]. 2020. Effects of Angiotensin-Converting Enzyme Inhibitors on Arterial Stiffness: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Cardiovascular Therapeutics،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1138625
Modern Language Association (MLA)
Li, Xiuli…[et al.]. Effects of Angiotensin-Converting Enzyme Inhibitors on Arterial Stiffness: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Cardiovascular Therapeutics No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1138625
American Medical Association (AMA)
Li, Xiuli& Chang, Peng& Wang, Qiongying& Hu, Hao& Bai, Feng& Li, Ningyin…[et al.]. Effects of Angiotensin-Converting Enzyme Inhibitors on Arterial Stiffness: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Cardiovascular Therapeutics. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1138625
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138625