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Carotid Disease and Ageing: A Literature Review on the Pathogenesis of Vascular Senescence in Older Subjects
Joint Authors
Zografos, Georgios
Sertedaki, Eleni
Veroutis, Dimitris
Filis, Konstadinos
Papalambros, Alexandros
Aggeli, Konstantina
Tsioli, Panagiota
Charalambous, George
Sigala, Fragiska
Galyfos, George
Zagouri, Flora
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aging is a natural process that affects all systems of the human organism, leading to its inability to adapt to environmental changes.
Advancing age has been correlated with various pathological conditions, especially cardiovascular and cerebrovascular diseases.
Carotid artery (CA) is mainly affected by age-induced functional and morphological alterations causing atheromatous disease.
The evolvement of biomedical sciences has allowed the elucidation of many aspects of this condition.
Symptomatic carotid disease (CD) derives from critical luminar stenosis or eruption of an atheromatous plaque due to structural modifications of the vessels, such as carotid intima-media thickening.
At a histologic level, the aforementioned changes are mediated by elastin fragmentation, collagen deposition, immune cell infiltration, and accumulation of cytokines and vasoconstrictors.
Underlying mechanisms include chronic inflammation and oxidative stress, dysregulation of cellular homeostatic systems, and senescence.
Thus, there is an imbalance in components of the vessel wall, which fails to counteract exterior stress stimuli.
Consequently, arterial relaxation is impaired and atherosclerotic lesions progress.
This is a review of current evidence regarding the relationship of aging with vascular senescence and CD.
A deeper understanding of these mechanisms can contribute to the production of efficient prevention methods and targeted therapeutic strategies.
American Psychological Association (APA)
Sertedaki, Eleni& Veroutis, Dimitris& Zagouri, Flora& Galyfos, George& Filis, Konstadinos& Papalambros, Alexandros…[et al.]. 2020. Carotid Disease and Ageing: A Literature Review on the Pathogenesis of Vascular Senescence in Older Subjects. Current Gerontology and Geriatrics Research،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138675
Modern Language Association (MLA)
Sertedaki, Eleni…[et al.]. Carotid Disease and Ageing: A Literature Review on the Pathogenesis of Vascular Senescence in Older Subjects. Current Gerontology and Geriatrics Research No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1138675
American Medical Association (AMA)
Sertedaki, Eleni& Veroutis, Dimitris& Zagouri, Flora& Galyfos, George& Filis, Konstadinos& Papalambros, Alexandros…[et al.]. Carotid Disease and Ageing: A Literature Review on the Pathogenesis of Vascular Senescence in Older Subjects. Current Gerontology and Geriatrics Research. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138675
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138675