Vitamin D Modulates Hematological Parameters and Cell Migration into Peritoneal and Pulmonary Cavities in Alloxan-Diabetic Mice
Joint Authors
Martins, Joilson O.
Tessaro, Fernando H. G.
Bella, Leonardo M.
Fieri, Isis
Nolasco, Eduardo L.
Nunes, Fernanda P. B.
Ferreira, Sabrina S.
Azevedo, Carolina B.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background/Aims.
The effects of cholecalciferol supplementation on the course of diabetes in humans and animals need to be better understood.
Therefore, this study investigated the effect of short-term cholecalciferol supplementation on biochemical and hematological parameters in mice.
Methods.
Male diabetic (alloxan, 60 mg/kg i.v., 10 days) and nondiabetic mice were supplemented with cholecalciferol for seven days.
The following parameters were determined: serum levels of 25-hydroxyvitamin D, phosphorus, calcium, urea, creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, red blood cell count, white blood cell count (WBC), hematocrit, hemoglobin, differential cell counts of peritoneal lavage (PeL), and bronchoalveolar lavage (BAL) fluids and morphological analysis of lung, kidney, and liver tissues.
Results.
Relative to controls, cholecalciferol supplementation increased serum levels of 25-hydroxyvitamin D, calcium, hemoglobin, hematocrit, and red blood cell counts and decreased leukocyte cell counts of PeL and BAL fluids in diabetic mice.
Diabetic mice that were not treated with cholecalciferol had lower serum calcium and albumin levels and hemoglobin, WBC, and mononuclear blood cell counts and higher serum creatinine and urea levels than controls.
Conclusion.
Our results suggest that cholecalciferol supplementation improves the hematological parameters and reduces leukocyte migration into the PeL and BAL lavage of diabetic mice.
American Psychological Association (APA)
Bella, Leonardo M.& Fieri, Isis& Tessaro, Fernando H. G.& Nolasco, Eduardo L.& Nunes, Fernanda P. B.& Ferreira, Sabrina S.…[et al.]. 2017. Vitamin D Modulates Hematological Parameters and Cell Migration into Peritoneal and Pulmonary Cavities in Alloxan-Diabetic Mice. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138692
Modern Language Association (MLA)
Bella, Leonardo M.…[et al.]. Vitamin D Modulates Hematological Parameters and Cell Migration into Peritoneal and Pulmonary Cavities in Alloxan-Diabetic Mice. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1138692
American Medical Association (AMA)
Bella, Leonardo M.& Fieri, Isis& Tessaro, Fernando H. G.& Nolasco, Eduardo L.& Nunes, Fernanda P. B.& Ferreira, Sabrina S.…[et al.]. Vitamin D Modulates Hematological Parameters and Cell Migration into Peritoneal and Pulmonary Cavities in Alloxan-Diabetic Mice. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138692