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Molecular and Histopathological Changes Associated with Keratoconus
Joint Authors
Khaled, Mariam Lotfy
Helwa, Inas
Drewry, Michelle
Seremwe, Mutsa
Estes, Amy
Liu, Yutao
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-30
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Keratoconus (KC) is a corneal thinning disorder that leads to loss of visual acuity through ectasia, opacity, and irregular astigmatism.
It is one of the leading indicators for corneal transplantation in the Western countries.
KC usually starts at puberty and progresses until the third or fourth decade; however its progression differs among patients.
In the keratoconic cornea, all layers except the endothelium have been shown to have histopathological structural changes.
Despite numerous studies in the last several decades, the mechanisms of KC development and progression remain unclear.
Both genetic and environmental factors may contribute to the pathogenesis of KC.
Many previous articles have reviewed the genetic aspects of KC, but in this review we summarize the histopathological features of different layers of cornea and discuss the differentially expressed proteins in the KC-affected cornea.
This summary will help emphasize the major molecular defects in KC and identify additional research areas related to KC, potentially opening up possibilities for novel methods of KC prevention and therapeutic intervention.
American Psychological Association (APA)
Khaled, Mariam Lotfy& Helwa, Inas& Drewry, Michelle& Seremwe, Mutsa& Estes, Amy& Liu, Yutao. 2017. Molecular and Histopathological Changes Associated with Keratoconus. BioMed Research International،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1138709
Modern Language Association (MLA)
Khaled, Mariam Lotfy…[et al.]. Molecular and Histopathological Changes Associated with Keratoconus. BioMed Research International No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1138709
American Medical Association (AMA)
Khaled, Mariam Lotfy& Helwa, Inas& Drewry, Michelle& Seremwe, Mutsa& Estes, Amy& Liu, Yutao. Molecular and Histopathological Changes Associated with Keratoconus. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1138709
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138709